Division of Advanced Pharmaceutics, Department of Clinical Pharmaceutical Sciences, School of Pharmacy, Iwate Medical University, Iwate, Japan.
Department of Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Teikyo Heisei University, Tokyo, Japan.
J Texture Stud. 2021 Jun;52(3):380-388. doi: 10.1111/jtxs.12589. Epub 2021 Feb 7.
Food thickening agents help patients with dysphagia to eat, drink, and take medications. Taking medications with food thickeners has been reported to cause problems such as reduction of pharmacological effects through the delayed disintegration or non-disintegration of tablets. We previously reported that long immersion periods in food thickeners causes delayed disintegration and non-disintegration, while an immersion time of 1 min prevents these problems. However, in many studies including ours, water was used as the solvent, and patients with dysphagia use various drinks as food thickener solvents. Therefore, in this study, we examined the effects on tablet disintegration of food thickeners dissolved in 12 solvents. The line spread test (LST) and pH of the food thickeners differed among solvents, whereas the disintegration times of tablets immersed in food thickeners for 1 min were similar. Magnesium oxide tablets immersed in food thickeners for 30 min experienced delayed disintegration or non-disintegration in all solvents. These results suggested that the effects of solvents on the disintegration of medications hardly differ. Therefore, patients taking medications with food thickeners may refer to reports in which water was used as the solvent, regardless of their drink of choice.
食品增稠剂有助于吞咽困难的患者进食、饮水和服用药物。有报道称，服用药物时使用食品增稠剂会导致一些问题，例如通过片剂延迟崩解或不崩解而降低药效。我们之前曾报道过长时间浸泡在食品增稠剂中会导致延迟崩解和不崩解，而浸泡 1 分钟可以防止这些问题。然而，在包括我们的研究在内的许多研究中，水被用作溶剂，而吞咽困难的患者则将各种饮料用作食品增稠剂的溶剂。因此，在这项研究中，我们研究了 12 种溶剂中溶解的食品增稠剂对片剂崩解的影响。线扩散试验（LST）和 pH 值因溶剂而异，而将片剂浸泡在食品增稠剂中 1 分钟的崩解时间相似。将氧化镁片剂浸泡在 30 分钟的食品增稠剂中，在所有溶剂中均出现延迟崩解或不崩解的情况。这些结果表明，溶剂对药物崩解的影响几乎没有差异。因此，服用药物和食品增稠剂的患者可以参考以水为溶剂的报告，而不必考虑他们选择的饮料。
