Zhou Fuli, Chen Fan, Ouyang Ziwei, Zhu Rendi, Zhou Renpeng, Hu Wei, Lu Chao
Department of Clinical Pharmacology, The Second Hospital of Anhui Medical University, Hefei, China.
The Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China.
Antioxid Redox Signal. 2024 Feb;40(4-6):329-344. doi: 10.1089/ars.2022.0139. Epub 2023 Mar 27.
Oxidative stress is a common feature of autoimmune diseases. Low levels of reactive oxygen species (ROS) generation are important for various biological processes. Redox homeostasis can be disrupted when there is an imbalance between the production of ROS and the detoxification effect of antioxidants. Peroxiredoxins (PRDXs) are essential regulators of cellular redox signaling. PRDXs are widely expressed antioxidant enzymes, and their physiological role is mainly to remove excess ROS in cells and reduce oxidative stress. Recent studies have shown that almost all PRDX subtypes are involved in the development of autoimmune diseases. The pathogenesis of autoimmune diseases is complex, and effective treatments are lacking. Therefore, there is an urgent need to find new therapeutic targets. In this review, we discuss the functions of PRDXs and their pathophysiological roles in several autoimmune diseases. PRDXs may serve as potential targets for the treatment of autoimmune diseases. PRDXs are important in oxidative stress-mediated pathological situations. Future in-depth exploration of the mechanisms involved in regulating PRDXs in autoimmune diseases is needed to develop strategies targeting PRDXs for the treatment of autoimmune diseases. 40, 329-344.
氧化应激是自身免疫性疾病的一个共同特征。低水平的活性氧（ROS）生成对各种生物过程很重要。当ROS的产生与抗氧化剂的解毒作用之间失衡时，氧化还原稳态可能会被破坏。过氧化物还原酶（PRDXs）是细胞氧化还原信号的重要调节因子。PRDXs是广泛表达的抗氧化酶，其生理作用主要是清除细胞内过量的ROS并减轻氧化应激。最近的研究表明，几乎所有PRDX亚型都参与了自身免疫性疾病的发展。自身免疫性疾病的发病机制复杂，且缺乏有效的治疗方法。因此，迫切需要找到新的治疗靶点。在本综述中，我们讨论了PRDXs的功能及其在几种自身免疫性疾病中的病理生理作用。PRDXs可能作为治疗自身免疫性疾病的潜在靶点。PRDXs在氧化应激介导的病理情况下很重要。未来需要深入探索自身免疫性疾病中调节PRDXs的机制，以制定针对PRDXs治疗自身免疫性疾病的策略。40, 329 - 344。
