First Department of Oncology, the Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning, China.
Department of Emergency, the Fourth Affiliated Hospital of China Medical University, Shenyang 110032, Liaoning, China.
Biomed Pharmacother. 2023 Aug;164:114896. doi: 10.1016/j.biopha.2023.114896. Epub 2023 May 19.
Oxidative stress is one of the hallmarks of cancer. Tumorigenesis and progression are accompanied by elevated reactive oxygen species (ROS) levels and adaptive elevation of antioxidant expression levels. Peroxiredoxins (PRDXs) are among the most important antioxidants and are widely distributed in a variety of cancers. PRDXs are involved in the regulation of a variety of tumor cell phenotypes, such as invasion, migration, epithelial-mesenchymal transition (EMT) and stemness. PRDXs are also associated with tumor cell resistance to cell death, such as apoptosis and ferroptosis. In addition, PRDXs are involved in the transduction of hypoxic signals in the TME and in the regulation of the function of other cellular components of the TME, such as cancer-associated fibroblasts (CAFs), natural killer (NK) cells and macrophages. This implies that PRDXs are promising targets for cancer treatment. Of course, further studies are needed to realize the clinical application of targeting PRDXs. In this review, we highlight the role of PRDXs in cancer, summarizing the basic features of PRDXs, their association with tumorigenesis, their expression and function in cancer, and their relationship with cancer therapeutic resistance.
氧化应激是癌症的标志之一。肿瘤发生和进展伴随着活性氧（ROS）水平的升高和抗氧化剂表达水平的适应性升高。过氧化物酶（PRDXs）是最重要的抗氧化剂之一，广泛分布于各种癌症中。PRDXs 参与调节多种肿瘤细胞表型，如侵袭、迁移、上皮-间充质转化（EMT）和干性。PRDXs 还与肿瘤细胞对细胞死亡的抵抗有关，如细胞凋亡和铁死亡。此外，PRDXs 参与肿瘤微环境中缺氧信号的转导以及肿瘤微环境中其他细胞成分（如癌相关成纤维细胞（CAFs）、自然杀伤（NK）细胞和巨噬细胞）功能的调节。这意味着 PRDXs 是癌症治疗的有前途的靶点。当然，需要进一步的研究来实现靶向 PRDXs 的临床应用。在这篇综述中，我们强调了 PRDXs 在癌症中的作用，总结了 PRDXs 的基本特征、它们与肿瘤发生的关系、它们在癌症中的表达和功能以及它们与癌症治疗抵抗的关系。
