Department of Periodontology, Eastman Institute for Oral Health, University of Rochester, New York, USA.
Clinical Research and Biostatistics, Eastman Institute for Oral Health, University of Rochester, New York, USA.
J Periodontol. 2023 Aug;94(8):1008-1017. doi: 10.1002/JPER.22-0690. Epub 2023 Mar 2.
Selective serotonin reuptake inhibitors (SSRIs) are used for the management of anxiety and depression. Existing evidence shows their negative impact on implant osseointegration, survival rates, and peri-implant health. Currently, there are limited data on their effect on peri-implant marginal bone levels. The primary goal of this retrospective study is to evaluate the association between SSRIs use and marginal bone level (MBL) changes around osseointegrated dental implants over time.
Records from patients who received at least one dental implant between 2010 and 2021 were reviewed. Information related to medical history, SSRI use, and the implant site was obtained from patients' electronic charts. Mesial and distal MBLs were measured relative to the implant platform on digital intraoral radiographs, taken at the time of prosthesis installation and at the most recent follow-up visit. MBL changes were calculated.
A total of 152 dental implants from 105 patients were included. The mean follow-up period was 46.97 ± 21.87 months. The mean MBL change was significantly greater for SSRI users (0.41 ± 0.76 mm) compared to non-users (0.04 ± 0.65 mm) [MD = 0.37 mm, p = 0.00, 95% CI: (-0.61)-(-0.15 mm)]. Mesial MBL change of 0.42 ± 0.84 mm and 0.02 ± 0.71 mm was noted for SSRI users and non-users, respectively. The distal MBL change was 0.4 ± 0.93 mm and 0.07 ± 0.73 mm, respectively. Smoking, sex, and implant location did not seem to influence the MBL differences between groups.
Use of SSRIs is associated with greater marginal bone loss around osseointegrated dental implants in function for a mean period of 3.8 years.
选择性 5-羟色胺再摄取抑制剂（SSRIs）被用于焦虑和抑郁的治疗。现有证据表明，它们会对种植体骨整合、存活率和种植体周围健康产生负面影响。目前，关于它们对种植体边缘骨水平影响的数据有限。本回顾性研究的主要目的是评估 SSRIs 使用与种植体骨整合后随时间推移种植体边缘骨水平（MBL）变化之间的关系。
回顾了 2010 年至 2021 年间至少接受过一颗种植牙的患者的记录。从患者的电子病历中获取了与病史、SSRIs 使用情况和种植体部位相关的信息。在修复体安装时和最近的随访时，通过数字化口内 X 光片测量种植体平台的近中和远中 MBL，并计算 MBL 变化。
共纳入了 105 名患者的 152 颗种植牙。平均随访时间为 46.97±21.87 个月。与非使用者（0.04±0.65mm）相比，SSRIs 使用者的 MBL 变化平均值显著更大（0.41±0.76mm）[MD=0.37mm，p=0.00，95%CI：（-0.61）-（-0.15mm）]。SSRIs 使用者和非使用者的近中 MBL 变化分别为 0.42±0.84mm 和 0.02±0.71mm。远中 MBL 变化分别为 0.40±0.93mm 和 0.07±0.73mm。吸烟、性别和种植体位置似乎并未影响两组间的 MBL 差异。
SSRIs 使用与种植体骨整合后 3.8 年内边缘骨丢失增加有关。
