Fujioka T, Tanji S, Koike H, Kumagai K, Suzuki K, Aoki H, Banya Y, Kubo T, Ohhori T
Department of Urology, School of Medicine, Iwate Medical University.
Hinyokika Kiyo. 1987 Jun;33(6):832-7.
In 8 cases of operable renal cancer, selective intraarterial infusion of the streptococcal preparation, OK-432 was performed and its cytocidal effects on the surgical specimens, which were removed on the 8th day after infusion, were investigated histopathologically with immunological parameters of the peripheral blood. The histopathological study revealed a high grade of sinus histiocytosis of the renal pedicle lymph nodes, but the anti-tumor effect on renal tumors was not so marked in any of the 8 cases. OK-Ia-positive lymphoid cells of peripheral blood were increased significantly and Con-A stimulation index of blastogenesis was lowered without any change in the PHA stimulation index after the OK-432 infusion. No serious complications of the selective intraarterial infusion were experienced except for high fever (less than 38 degrees C). In conclusion, OK-432 selective intraarterial infusion was an effective method for improving regional and systemic immunoactivity, but the cytocidal effect against tumor cells could not be confirmed histopathologically.
对8例可手术切除的肾癌患者进行了选择性肾动脉内注射链球菌制剂OK-432，并于注射后第8天切除手术标本，通过外周血免疫参数对其杀细胞作用进行了组织病理学研究。组织病理学研究显示肾蒂淋巴结有高度的窦组织细胞增生，但8例患者中对肾肿瘤均未显示出明显的抗肿瘤作用。注射OK-432后外周血OK-Ia阳性淋巴细胞显著增加，母细胞化的刀豆蛋白A刺激指数降低，而植物血凝素刺激指数无变化。除高热（低于38摄氏度）外，未出现选择性肾动脉内注射的严重并发症。总之，OK-432选择性肾动脉内注射是改善局部和全身免疫活性的有效方法，但组织病理学上未能证实其对肿瘤细胞的杀细胞作用。
