Kato M, Ishiwata D, Kakehi R, Oshima N, Soma G, Mizuno D
Gan To Kagaku Ryoho. 1987 Jul;14(7):2378-80.
The strong tumor-selective cytocidal action of tumor necrosis factor (TNF) has been observed in vitro and in vivo. Sato et al. have reported that it was possible to induce a primed state of TNF triggering by injection of purified protein derivative (PPD) even a long time after BCG sensitization, suggesting that this treatment could be applied to human patients. In the present study, we achieved a partial response of a metastatic lesion in a patient with renal cancer by the induction of endogenous TNF by PPD and OK-432 (a streptococcal preparation). This study suggested the possible application of this therapy to also patients with malignant tumor which are highly resistant to any conventional antitumor therapy.
肿瘤坏死因子（TNF）强大的肿瘤选择性杀伤作用已在体内外观察到。佐藤等人报告称，即使在卡介苗致敏很长时间后，通过注射纯化蛋白衍生物（PPD）也有可能诱导TNF触发的致敏状态，这表明这种治疗方法可应用于人类患者。在本研究中，我们通过PPD和OK - 432（一种链球菌制剂）诱导内源性TNF，使一名肾癌患者的转移病灶获得了部分缓解。本研究表明，这种疗法也可能适用于对任何传统抗肿瘤疗法高度耐药的恶性肿瘤患者。
