State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China; Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin 300381, China.
Biomed Pharmacother. 2023 Apr;160:114344. doi: 10.1016/j.biopha.2023.114344. Epub 2023 Feb 2.
All species have a physiological need for sleep, and sleep is crucial for the preservation and restoration of many physiological processes in the body. Recent research on the effects of gut microbiota on brain function has produced essential data on the relationship between them. It has been discovered that dysregulation of the gut-brain axis is related to insomnia. Certain metabolites of gut microbiota have been linked to insomnia, and disturbances in gut microbiota can worsen insomnia. Traditional Chinese medicine (TCM) has unique advantages for the treatment of insomnia. Taking the gut microbiota as the target and determining the scientific relevance of TCM to the prevention and treatment of insomnia may lead to new concepts for the treatment of sleep disorders and improve the therapeutic effect of sleep. Taking the gut microbiota as an entry point, this paper reviews the relationship between gut microbiota and TCM, the relationship between gut microbiota and insomnia, the mechanism by which gut microbiota regulate sleep, and the mechanism by which TCM regulates gut microbiota for insomnia prevention and treatment. This review provides new ideas for the prevention and treatment of insomnia through TCM and new ideas for drug development.
所有物种都有生理上的睡眠需求，睡眠对于维持和恢复身体的许多生理过程至关重要。最近关于肠道微生物群对大脑功能影响的研究为它们之间的关系提供了重要数据。已经发现，肠道-大脑轴的失调与失眠有关。肠道微生物群的某些代谢物与失眠有关，而肠道微生物群的紊乱会使失眠恶化。中医药（TCM）在治疗失眠方面具有独特的优势。以肠道微生物群为靶点，确定 TCM 对失眠的预防和治疗的科学相关性，可能会为治疗睡眠障碍带来新的概念，并提高睡眠的治疗效果。以肠道微生物群为切入点，本文综述了肠道微生物群与 TCM 的关系、肠道微生物群与失眠的关系、肠道微生物群调节睡眠的机制以及 TCM 调节肠道微生物群治疗失眠的机制。这为通过 TCM 预防和治疗失眠提供了新的思路，也为药物开发提供了新的思路。
