朝鲜冷杉叶中的三萜类化合物及其生物活性。

Triterpenoids from the leaves of Abies koreana and their biological activities.

作者信息

Lee Dong Jun, Hong Seong-Min, Yoon Da Hye, Ham Song Lim, Kim Jonghwan, Kim Sun Yeou, Choi Sang Un, Kim Chung Sub, Lee Kang Ro

机构信息

Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon, 16419, Republic of Korea.

Gachon Institute of Pharmaceutical Science, Gachon University, 191 Hambakmoero, Yeonsu-gu, Incheon, 21936, Republic of Korea; College of Pharmacy, Gachon University, 191 Hambakmoero, Yeonsu-gu, Incheon, 21936, Republic of Korea.

出版信息

Phytochemistry. 2023 Apr;208:113594. doi: 10.1016/j.phytochem.2023.113594. Epub 2023 Feb 3.

DOI:10.1016/j.phytochem.2023.113594

PMID:36738908

Abstract

Seven undescribed triterpenoids, abikoranes A-G, along with three known triterpenoids were isolated from the leaves of Abies koreana E. H. Wilson. The structures of compounds were elucidated by 1D and 2D NMR, HRMS, ECD, specific rotation, and DP4+ analysis. Abikorane A represents the second example of nor-3,4-seco-17,14-friedo-lanostane triterpenoid. Among the isolates, some compounds showed strong cytotoxic activities against some of four tested cancer cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-116) with the values of IC 0.89-9.62 μM, inhibited lipopolysaccharide-stimulated nitric oxide production with IC values of 11.57-15.16 μM, and exhibited significant nerve growth factor release effect (192.54 ± 12.33%) from C6 glioma cells.

摘要

从朝鲜冷杉（Abies koreana E. H. Wilson）的叶子中分离出了7种未描述的三萜类化合物，即阿比科烷A - G，以及3种已知的三萜类化合物。通过一维和二维核磁共振、高分辨质谱、电子圆二色谱、比旋光度和DP4 +分析确定了化合物的结构。阿比科烷A是去甲-3,4-断-17,14-失碳羊毛甾烷三萜类化合物的第二个实例。在分离出的化合物中，一些化合物对四种测试癌细胞系（A549、SK - OV - 3、SK - MEL - 2和HCT - 116）中的某些细胞系表现出较强的细胞毒性活性，IC值为0.89 - 9.62 μM，对脂多糖刺激的一氧化氮产生有抑制作用，IC值为11.57 - 15.16 μM，并对C6胶质瘤细胞表现出显著的神经生长因子释放效应（192.54 ± 12.33%）。