接种 COVID-19 疫苗后出现系统性红斑狼疮性心肌炎。

Systemic lupus erythematosus myocarditis after COVID-19 vaccination.

机构信息

Internal Medicine Department, Clínica Universidad de Navarra, Pamplona, Spain.

出版信息

Reumatol Clin (Engl Ed). 2023 Feb;19(2):114-116. doi: 10.1016/j.reumae.2022.06.006.

DOI:10.1016/j.reumae.2022.06.006

PMID:36739118

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9892927/

Abstract

INTRODUCTION

Cases of acute myocarditis have been after administration of the BNT162b2 and Ad26.COV2.S vaccine.

OBJECTIVE

Describe another possible mechanism of myocarditis after COVID-19 vaccination.

CASE PRESENTATION

We describe the clinical case of a 72-year-old female with pleuritic chest pain one week after the third of the BNT162b2 mRNA vaccine. Serological tests for cardiotropic pathogens were negative, and autoimmunity screening was positive with anti-nuclear antibody (ANA) in 1:160 dilution, Anti-double-stranded DNA (anti-dsDNA), and anti-histone antibodies. F-fluoro-deoxy-glucose (FDG) positron emission tomography/computed tomography (PET/CT) showed a focal myocardial and pericardial inflammatory process in the cardiac apex.

RESULTS AND DISCUSSION

Systemic lupus erythematosus (SLE) diagnosis was made with myocardial affection. As far as we know, this is the first report of a case of lupus myocarditis after the COVID-19 vaccine.

CONCLUSION

Given the pathogenic rationales, the association between SLE and myocarditis should be considered.

摘要

简介

在接种 BNT162b2 和 Ad26.COV2.S 疫苗后，出现了急性心肌炎病例。

目的

描述 COVID-19 疫苗接种后心肌炎的另一种可能机制。

病例介绍

我们描述了一例 72 岁女性的临床病例，她在接种 BNT162b2 mRNA 疫苗的第三剂后一周出现胸膜炎性胸痛。心肌病原体的血清学检测为阴性，自身免疫筛查呈阳性，抗核抗体（ANA）滴度为 1:160，抗双链 DNA（抗 dsDNA）和抗组蛋白抗体。氟代脱氧葡萄糖（FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）显示心尖部局灶性心肌和心包炎症过程。