尼古丁暴露降低了 hACE2 小鼠大脑中 SARS-CoV-2 RNA 表达和神经病理学的可能性，但不能降低濒死率。

Neurobiology Laboratory, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA.

Bioinformatics Support Group, Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC, USA.

Sci Rep. 2023 Feb 4;13(1):2042. doi: 10.1038/s41598-023-29118-6.

Individuals infected by SARS-CoV-2 are at risk of developing neurological-related post-acute disorders. Disputed epidemiological data indicated nicotine may reduce the severity of infection. Here we find exposure to nicotine in drinking water does not alter the moribundity of hACE2 mice. However, pre-exposure to nicotine decreased the likelihood of SARS-CoV-2 RNA expression and pathology in the brain. These results suggest mechanisms involving targets of nicotine could be leveraged to prevent the neurovirulence of SARS-CoV-2.

感染 SARS-CoV-2 的个体有发生神经相关的急性后期疾病的风险。有争议的流行病学数据表明，尼古丁可能减轻感染的严重程度。在这里，我们发现饮用水中的尼古丁暴露不会改变 hACE2 小鼠的濒死率。然而，尼古丁预先暴露降低了 SARS-CoV-2 RNA 在大脑中的表达和病理学发生的可能性。这些结果表明，涉及尼古丁作用靶点的机制可能被利用来预防 SARS-CoV-2 的神经毒力。