选择性剖宫产术后胎盘色氨酸降解酶表达和母体外周血犬尿氨酸/色氨酸比值。
Tryptophan degradation enzymes expression in the placenta and the Kynurenine/Tryptophan ratio in maternal plasma after elective cesarean section.
机构信息
Department of Health Sciences, Division of Obstetrics and Gynecology, Careggi Hospital, University of Florence, Florence, Italy.
Department of Statistics, Computer Science, Applications, University of Florence, Florence, Italy.
出版信息
J Reprod Immunol. 2023 Mar;156:103823. doi: 10.1016/j.jri.2023.103823. Epub 2023 Feb 1.
Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) metabolize tryptophan in the kynurenine pathway. We evaluated these enzymes' mRNA expression in maternal and fetal sides of the placenta of uncomplicated, unlabored full-term pregnancies after elective cesarean section and compared it with that of placentas obtained from vaginal delivery. Tryptophan and kynurenine plasmatic levels after cesarean section were measured, to investigate their possible correlation with IDO1 and TDO mRNA (TDO2) expression. The results suggested that IDO1 and TDO2 expression was higher in the maternal side of the placenta and that labor significantly affects TDO2 expression and the plasma Kynurenine/Tryptophan ratio.
色氨酸 2,3-双加氧酶 1（IDO1）和色氨酸 2,3-双加氧酶（TDO）在犬尿氨酸途径中代谢色氨酸。我们评估了这些酶在择期剖宫产的无并发症、未分娩的足月妊娠产妇和阴道分娩胎盘的母侧和胎儿侧的 mRNA 表达，并与它们进行了比较。测量了剖宫产术后色氨酸和犬尿氨酸的血浆水平，以研究它们与 IDO1 和 TDO mRNA（TDO2）表达的可能相关性。结果表明，IDO1 和 TDO2 在胎盘的母侧表达更高，而分娩显著影响 TDO2 的表达和血浆犬尿氨酸/色氨酸比值。
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