Dali Rafik, Estrada-Meza Judith, Langlet Fanny
Department of biomedical sciences, University of Lausanne, 1005 Lausanne, Switzerland.
Department of biomedical sciences, University of Lausanne, 1005 Lausanne, Switzerland.
Physiol Behav. 2023 May 1;263:114108. doi: 10.1016/j.physbeh.2023.114108. Epub 2023 Feb 3.
Reciprocal communication between neurons and glia is essential for normal brain functioning and adequate physiological functions, including energy balance. In vertebrates, the homeostatic process that adjusts food intake and energy expenditure in line with physiological requirements is tightly controlled by numerous neural cell types located within the hypothalamus and the brainstem and organized in complex networks. Within these neural networks, peculiar ependymoglial cells called tanycytes are nowadays recognized as multifunctional players in the physiological mechanisms of appetite control, partly by modulating orexigenic and anorexigenic neurons. Here, we review recent advances in tanycytes' impact on hypothalamic neuronal activity, emphasizing on arcuate neurons.
神经元与神经胶质细胞之间的相互通讯对于正常的脑功能以及包括能量平衡在内的适当生理功能至关重要。在脊椎动物中，根据生理需求调节食物摄入和能量消耗的稳态过程，受到位于下丘脑和脑干内并组织成复杂网络的众多神经细胞类型的严格控制。在这些神经网络中，一种称为伸长细胞的特殊室管膜神经胶质细胞，如今被认为是食欲控制生理机制中的多功能参与者，部分原因是通过调节促食欲和抑食欲神经元来实现的。在此，我们综述了伸长细胞对下丘脑神经元活动影响的最新进展，重点关注弓状核神经元。
