Nishi Takeshi, Kume Teruyoshi, Yamada Ryotaro, Koto Satsohi, Sasahira Yoshitaka, Okamoto Hiroshi, Tamada Tomoko, Koyama Terumasa, Imai Koichiro, Neishi Yoji, Ughi Giovanni J, Uemura Shiro
Department of Cardiology, Kawasaki Medical School, Kurashiki, Okayama, Japan.
Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Catheter Cardiovasc Interv. 2023 Feb;101(3):520-527. doi: 10.1002/ccd.30573. Epub 2023 Feb 5.
We sought to investigate whether a novel, fast-pullback, high-frequency optical coherence tomography (HF-OCT) imaging system enables data acquisition with a reduced amount of contrast agents while retaining the same qualitative and quantitative lesion assessment to conventional OCT.
The increased amount of administered contrast agents is a major concern when performing intracoronary OCT.
The present study is a single-center, prospective, observational study including 10 patients with stable coronary artery disease. A total of 28 individual coronary arteries were assessed by both fast-pullback HF-OCT and by conventional OCT.
The contrast volume used in each OCT run for the HF-OCT system was significantly lower than for the conventional OCT system (5.0 ± 0.0 mL vs. 7.8 ± 0.7 mL, respectively, with a mean difference of -2.84 [95% confidence interval [CI]: -3.10 to -2.58]). No significant difference was found in the median value of the clear image length between the two OCT systems (74 mm [interquartile range [IQR]; 63, 81], 74 mm [IQR; 71, 75], p = 0.89). Fast-pullback HF-OCT showed comparable measurements to conventional OCT, including minimum lumen area (3.27 ± 1.53 mm vs. 3.21 ± 1.53 mm , p = 0.27), proximal reference area (7.03 ± 2.28 mm vs. 7.03 ± 2.34 mm , p = 0.96), and distal reference area (5.93 ± 1.96 mm vs. 6.03 ± 2.02 mm , p = 0.23). Qualitative OCT findings were comparable between the fast-pullback HF-OCT runs and conventional OCT with respect to identifying lipid-rich plaques, calcifications, layered plaques, macrophages, and cholesterol crystals.
With the fast pullback function of a novel HF-OCT imaging system, we acquired OCT images using a significantly lower amount of contrast volume while retaining a comparable qualitative and quantitative lesion assessment to conventional OCT.
我们旨在研究一种新型的、快速回撤的高频光学相干断层扫描（HF-OCT）成像系统是否能够在减少造影剂用量的情况下进行数据采集，同时保持与传统 OCT 相同的定性和定量病变评估。
在进行冠状动脉内 OCT 检查时，造影剂用量的增加是一个主要问题。
本研究是一项单中心、前瞻性、观察性研究，纳入了 10 例稳定型冠状动脉疾病患者。共对 28 条冠状动脉分别进行了快速回撤 HF-OCT 和传统 OCT 评估。
HF-OCT 系统每次 OCT 检查所使用的造影剂体积显著低于传统 OCT 系统（分别为 5.0±0.0 mL 和 7.8±0.7 mL，平均差值为 -2.84 [95% 置信区间 [CI]：-3.10 至 -2.58]）。两种 OCT 系统之间清晰图像长度的中位数无显著差异（74 mm [四分位间距 [IQR]；63, 81]，74 mm [IQR；71, 75]，p = 0.89）。快速回撤 HF-OCT 显示出与传统 OCT 相当的测量结果，包括最小管腔面积（3.27±1.53 mm² 对 3.21±1.53 mm²，p = 0.27）、近端参考面积（7.03±2.28 mm² 对 7.03±2.34 mm²，p = 0.96）和远端参考面积（5.93±1.96 mm² 对 6.03±2.02 mm²，p = 0.23）。在识别富含脂质斑块、钙化、分层斑块、巨噬细胞和胆固醇晶体方面，快速回撤 HF-OCT 检查与传统 OCT 的定性 OCT 结果相当。
利用新型 HF-OCT 成像系统的快速回撤功能，我们在显著减少造影剂用量的情况下获取了 OCT 图像，同时保持了与传统 OCT 相当的定性和定量病变评估。
