Guo J, Zhang J X
School of Medicine, Wuhan University of Science and Technology, Wuhan 430065, China.
Zhonghua Shao Shang Yu Chuang Mian Xiu Fu Za Zhi. 2023 Jan 20;39(1):91-95. doi: 10.3760/cma.j.cn501225-20220531-00209.
Wound healing is one of the common pathophysiological processes in the body. How to improve the condition of wound healing to promote rapid wound healing has always been a hotspot in research. Oxidative stress is one of the important factors affecting wound healing. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a classic antioxidant stress factor as well as a factor with great potential in facilitating wound healing. The activation of Nrf2 can regulate the downstream antioxidant stress elements and play roles of anti-apoptosis and cell homeostasis maintaining, which improves wound healing environment and promotes wound repair. This paper summarized the common agonists and inhibitors of Nrf2 and reviewed the roles of Nrf2 in promoting skin wound healing including diabetic ulcers, radiation injury, and ischemia-reperfusion injury, etc.
伤口愈合是机体常见的病理生理过程之一。如何改善伤口愈合状况以促进伤口快速愈合一直是研究热点。氧化应激是影响伤口愈合的重要因素之一。核因子E2相关因子2（Nrf2）是经典的抗氧化应激因子，也是在促进伤口愈合方面具有巨大潜力的因子。Nrf2的激活可调节下游抗氧化应激元件，发挥抗凋亡和维持细胞稳态的作用，从而改善伤口愈合环境并促进伤口修复。本文综述了Nrf2常见的激动剂和抑制剂，并阐述了Nrf2在促进皮肤伤口愈合中的作用，包括糖尿病溃疡、辐射损伤和缺血再灌注损伤等。
