性别在抑郁症基因关联研究中的作用。
The Role of Sex in Genetic Association Studies of Depression.
作者信息
Hoth Karin F, Voorhies Kirsten, Wu Ann Chen, Lange Christoph, Potash James B, Lutz Sharon M
机构信息
Department of Psychiatry and Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242, USA.
Precision Medicine Translational Research Center (PROMoTeR), Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA 02215, USA.
出版信息
J Psychiatr Brain Sci. 2022;7(6). doi: 10.20900/jpbs.20220013. Epub 2022 Dec 30.
Depression is the most common mental illness in the U.S. affecting nearly 40 million adults age 18 years and older. Depression has both genetic and environmental influences. In addition, women are more likely to be affected by depression than men. However, the relationship between genes and depression is complex and may be influenced by sex. Understanding the genetic basis of sex-specific differences for depression has the potential to lead to new biological understanding of the etiology of depression in females compared to males and to promote the development of novel and more effective pharmacotherapies. This review examines the role of sex in genetic associations with depression for both genome-wide association and candidate gene studies. While the genetic association signals of depression differ by sex, the role of sex in the heritability of depression is complex and warrants further investigation.
抑郁症是美国最常见的精神疾病，影响着近4000万18岁及以上的成年人。抑郁症受到遗传和环境的双重影响。此外，女性比男性更容易患抑郁症。然而，基因与抑郁症之间的关系很复杂，可能受到性别的影响。了解抑郁症性别特异性差异的遗传基础，有可能带来对女性与男性抑郁症病因的新生物学认识，并促进新型更有效药物疗法的开发。这篇综述探讨了在全基因组关联研究和候选基因研究中，性别在与抑郁症的遗传关联中的作用。虽然抑郁症的遗传关联信号因性别而异，但性别在抑郁症遗传度中的作用很复杂，值得进一步研究。
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