Department of Medical Psychology of Harbin Medical University, Heilongjiang Province, China 150081.
Department of Medical Education Management, School of Health Management of Harbin Medical University, Harbin, China 150081.
Oxid Med Cell Longev. 2022 Jan 28;2022:2633127. doi: 10.1155/2022/2633127. eCollection 2022.
Based on the "oxidative stress hypothesis" of major depressive disorder (MDD), cells regulate their structure through the Wnt pathway. Little is known regarding the interactions of dishevelled 3 () and glycogen synthase kinase 3 beta () polymorphisms with MDD. The aim of the current study was to verify the relationship between and genetic variants in a Chinese Han population and further to evaluate whether these interactions exhibit gender-specificity. A total of 1136 participants, consisting of 541 MDD patients and 595 healthy subjects, were recruited. Five single-nucleotide polymorphisms (SNPs) of / were selected to assess their interaction by use of a generalized multifactor dimensionality reduction method. The genotype and haplotype frequencies of / polymorphisms were significantly different between patients and controls for rs1709642 ( < 0.01) and rs334558, rs6438552, and rs2199503 ( < 0.01). In addition, our results also showed that there were significant interaction effects between and polymorphisms and the risk of developing MDD, particularly in women. The interaction between (rs1709642) and (rs334558, rs6438552) showed a cross-validation (CV) consistency of 10/10, a value of 0.001, and a testing accuracy of 59.22%, which was considered as the best generalized multifactor dimensionality reduction (GMDR) model. This study reveals the interaction between and polymorphisms on MDD susceptibility in a female Chinese Han population. The effect of gender should be taken into account in future studies that seek to explore the genetic predisposition to MDD relative to the and genes.
基于重度抑郁症（MDD）的“氧化应激假说”，细胞通过 Wnt 途径调节其结构。关于盘状结构域 3（）和糖原合成酶激酶 3β（）多态性与 MDD 的相互作用知之甚少。本研究旨在验证中国汉族人群中与和多态性相关的遗传变异之间的关系，并进一步评估这些相互作用是否具有性别特异性。共招募了 1136 名参与者，包括 541 名 MDD 患者和 595 名健康对照者。使用广义多因子降维法评估了/的 5 个单核苷酸多态性（SNP）的相互作用。患者和对照组 rs1709642（<0.01）和 rs334558、rs6438552、rs2199503（<0.01）的/多态性基因型和单倍型频率差异有统计学意义。此外，我们的结果还表明，和多态性与 MDD 发病风险之间存在显著的相互作用效应，尤其是在女性中。（rs1709642）和（rs334558、rs6438552）之间的相互作用具有 10/10 的交叉验证（CV）一致性、0.001 的值和 59.22%的测试准确性，被认为是最佳广义多因子降维（GMDR）模型。本研究揭示了女性中国汉族人群中与多态性对 MDD 易感性的相互作用。在未来研究中，应该考虑性别因素，以探索与和基因相关的 MDD 遗传易感性。
