Rahimi Mehran, Faridi Leili, Nikniaz Leila, Daneshvar Sara, Naseri Amirreza, Taban-Sadeghi Mohammadreza, Manaflouyan Hesam, Shahabi Javad, Sarrafzadegan Nizal
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Heart Int. 2022 Aug 31;16(2):75-84. doi: 10.17925/HI.2022.16.2.75. eCollection 2022.
: Endothelial adhesion molecules (EAMs), and more specifically vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1), belong to a family of immunoglobulin-like molecules and are found to have increased expression in inflamed microvessels. Due to the growing evidence regarding EAM effects on cardiovascular diseases, we aimed to investigate the link between EAMs and atrial fibrillation (AF) to discover the efficacy of EAMs assessment as predictive markers in high-risk patients. : We searched for articles published from January 1990 to April 2022. Two independent researchers selected studies that examined the relationship between VCAM-1 and ICAM-1 levels and AF. Study design, patient characteristics, VCAM-1 and ICAM-1 levels, and measurement methods were extracted from the selected articles. : Of 181 records, 22 studies were finally included in the systematic review. Meta-analyses showed a significant difference in serum levels of EAMs in patients with AF compared with patients with sinus rhythms (VCAM-1: mean difference [MD] 86.782, 95% CI 22.805-150.758, p=0.008; ICAM-1: MD 28.439 ng/mL, 95% CI 12.540-44.338, p<0.001). In subgroup analysis of persistent AF, the differences were still significant (VCAM-1: MD 98.046, 95% CI 26.582-169.510, p=0.007; ICAM-1: MD 25.091, 95% CI 12.952-37.230, p<0.001). We also found the mean ranges of VCAM-1 (95% CI 661.394-927.984 ng/mL) and ICAM-1 (95% CI 190.101-318.169 ng/mL) in patients with AF. : This study suggests a positive association between serum levels of VCAM-1 and ICAM-1 with AF, but there is a need for further large-scale studies.
内皮黏附分子（EAMs），更具体地说是血管细胞黏附分子-1（VCAM-1）和细胞间黏附分子-1（ICAM-1），属于免疫球蛋白样分子家族，且发现在炎症微血管中表达增加。鉴于关于EAM对心血管疾病影响的证据越来越多，我们旨在研究EAMs与心房颤动（AF）之间的联系，以发现EAMs评估作为高危患者预测标志物的有效性。
我们检索了1990年1月至2022年4月发表的文章。两名独立研究人员筛选了研究VCAM-1和ICAM-1水平与AF之间关系的研究。从所选文章中提取研究设计、患者特征、VCAM-1和ICAM-1水平以及测量方法。
在181条记录中，最终有22项研究纳入系统评价。荟萃分析显示，与窦性心律患者相比，AF患者血清EAMs水平存在显著差异（VCAM-1：平均差异[MD]86.782，95%CI 22.805-150.758，p=0.008；ICAM-1：MD 28.439 ng/mL，95%CI 12.540-44.338，p<0.001）。在持续性AF的亚组分析中，差异仍然显著（VCAM-1：MD 98.046，95%CI 26.582-169.510，p=0.007；ICAM-1：MD 25.091，95%CI 12.952-37.230，p<0.001）。我们还发现了AF患者中VCAM-1（95%CI 661.394-927.984 ng/mL）和ICAM-1（95%CI 190.101-318.169 ng/mL）的平均范围。
本研究表明血清VCAM-1和ICAM-1水平与AF之间存在正相关，但仍需要进一步的大规模研究。
