孕期母体感染与儿童注意力缺陷多动障碍：一项系统评价与荟萃分析
Maternal Infection during Pregnancy and Attention-Deficit Hyperactivity Disorder in Children: A Systematic Review and Meta-Analysis.
作者信息
Ayubi Erfan, Mansori Kamyar
机构信息
Autism Spectrum Disorders Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Social Determinants of Health Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
出版信息
Iran J Public Health. 2022 Dec;51(12):2674-2687. doi: 10.18502/ijph.v51i12.11458.
BACKGROUND
We aimed to determine the association between maternal infections during pregnancy with risk of Attention-Deficit Hyperactivity Disorder (ADHD) in children.
METHODS
A systematic literature search was performed utilizing the online databases PubMed, Scopus, and Web of Sciences up to July 2020. Random-effects meta-analyses were applied to estimate pooled relative risk (RR). Heterogeneity, study quality and publication bias were assessed through I value, Newcastle-Ottawa scale (NOS) and Egger's test, respectively.
RESULTS
Thirteen articles involving 1401904 mother-child pairs were included. The result of meta-analysis showed that the risk of ADHD increased by 30% among children whose mothers took any infections during pregnancy (pooled RR=1.30, 95% CI: 1.14-1.49; I=85.5, P<0.001). Overall, the included studies were good in quality and no publication bias was found (=0.23, Egger's test).
CONCLUSION
Maternal infections during pregnancy might be associated with an increased risk of ADHD in children.
背景
我们旨在确定孕期母亲感染与儿童注意力缺陷多动障碍（ADHD）风险之间的关联。
方法
截至2020年7月，利用在线数据库PubMed、Scopus和Web of Sciences进行了系统的文献检索。采用随机效应荟萃分析来估计合并相对风险（RR）。分别通过I值、纽卡斯尔-渥太华量表（NOS）和Egger检验评估异质性、研究质量和发表偏倚。
结果
纳入了13篇文章，涉及1401904对母婴。荟萃分析结果显示，母亲在孕期发生任何感染的儿童患ADHD的风险增加了30%（合并RR = 1.30，95%CI：1.14 - 1.49；I = 85.5，P < 0.001）。总体而言，纳入的研究质量良好，未发现发表偏倚（Egger检验P = 0.23）。
结论
孕期母亲感染可能与儿童患ADHD的风险增加有关。
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