Nagarajan Pooja, Thangaraj Muthu Selvi
Chennai, Tamil Nadu India.
Department of Speech Language and Hearing Sciences, Sri Ramachandra Institute of Higher Education and Research (Deemed to be University), Porur, Chennai, 600116 Tamil Nadu India.
Indian J Otolaryngol Head Neck Surg. 2022 Dec;74(Suppl 3):4110-4116. doi: 10.1007/s12070-021-02856-7. Epub 2021 Sep 18.
The present study aimed to find the effect of glycerol administration on Electrocochleography (ECochG), cervical and ocular Vestibular Evoked Myogenic Potential (c-VEMP, o-VEMP) findings in individual with Meniere's disease. Sixteen participants (32 ears) diagnosed with Meniere's disease underwent ECochG, c-VEMP and o-VEMP for both pre and 1 h post-glycerol administration. Paired t-test indicated that the SP/AP ratio of ECochG measures was significantly improved with post-glycerol administration. There was no significant difference in the mean amplitude of o-VEMP and c-VEMP between pre and post-glycerol administration. However, while individual differences were compared, 75% of the participants reported either improvement in c-VEMP amplitude or newly emerging c-VEMP& o-VEMP. Based on the recommendation by Adams et al. (Otolaryngol Clin North Am 43(5):995-1009, 2010), the improvement on these tests results with post glycerol administration were considered as a significant indicator for the presence of Meniere's disease.With post glycerol administration, the present study found that 84%of participants were found to have an improvement in the amplitude for ECochG measures. There was an improvement in the amplitude measures of o-VEMP and c-VEMP, which were observed in 75% and 68%of participants respectively with post-glycerol administration. Improvement in the amplitude of test measures with post-glycerol administration were observed to be more for cochlear potentials of ECochG followed by vestibular potentials of c-VEMP and o-VEMP. Thus, improvement of ECochG amplitude with post-glycerol administration might serve as an additional indicator for the presence of Meniere's disease.
本研究旨在探究甘油给药对梅尼埃病患者的耳蜗电图（ECochG）、颈肌和眼肌前庭诱发肌源性电位（c-VEMP、o-VEMP）结果的影响。16名被诊断为梅尼埃病的参与者（32耳）在甘油给药前及给药后1小时均接受了ECochG、c-VEMP和o-VEMP检查。配对t检验表明，甘油给药后ECochG测量的SP/AP比值显著改善。甘油给药前后o-VEMP和c-VEMP的平均振幅无显著差异。然而，在比较个体差异时，75%的参与者报告c-VEMP振幅有所改善或新出现了c-VEMP和o-VEMP。根据亚当斯等人（《北美耳鼻咽喉科临床杂志》43(5):995-1009, 2010）的建议，甘油给药后这些测试结果的改善被视为梅尼埃病存在的重要指标。甘油给药后，本研究发现84%的参与者ECochG测量的振幅有所改善。甘油给药后，分别有75%和68%的参与者o-VEMP和c-VEMP的振幅测量有所改善。甘油给药后，测试指标振幅的改善在ECochG的耳蜗电位方面更为明显，其次是c-VEMP和o-VEMP的前庭电位。因此，甘油给药后ECochG振幅的改善可能作为梅尼埃病存在的额外指标。
