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腮腺内面神经鞘瘤的系统评价及病例报告

Systematic Review of Intra Parotid Facial Nerve Schwannoma and a Case Report.

作者信息

Singh Akhilesh Kumar, Kumar Janani Anand, Sharma Naresh Kumar, Pandey Arun, Mishra Nitesh, Bera Rathindranath

机构信息

Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, Institute of Medical Sciences, Banaras Hindu University, Varanasi, U.P. India.

Trauma Center and Superspeciality Hospital, Institute of Medical Sciences, Banaras Hindu University, Varanasi, U.P. India.

出版信息

Indian J Otolaryngol Head Neck Surg. 2022 Dec;74(Suppl 3):6268-6284. doi: 10.1007/s12070-021-03013-w. Epub 2022 Jan 15.

Abstract

To evaluate the clinico-epidemiological aspects, pathological features, diagnostic methods, management protocol and functional outcome of the intra-parotid facial nerve schwannoma (IFNS) and to present a case report on intra parotid facial nerve schwannoma. PubMed, ProQuest, Google scholar, Science direct and Scopus were screened for studies. Article selection and data extraction was done by one investigator and other investigator confirmed its accuracy. After abstract and text screening a total of 69 articles were finally selected for the study with the inclusion and exclusion criteria of the systematic review as per PRISMA guidelines. With addition of one case reported to our department. The mean age of diagnosis was 43 ± 16 years with a slight female predominance. The mean duration of the tumour was 29.5 months and the mean size of the tumour on initial diagnosis was 3.6 ± 1.67 cm. Pleomorphic adenoma was the primary diagnosis in 44 cases. Superficial parotidectomy was done in 64 cases followed by resection in 47 cases. Reconstructive treatment was carried out by an end-to-end anastomosis in 3 patients and by facial-hypoglossal anastomosis in 16 patients, GAN cable grafting in 5 patients, a greater auricular nerve graft was done in18 patients and end-to-side interposed sural nerve graft in 8 patients. The type D tumours are treated by extended resection of the facial nerve, which is difficult to reconstruct and also employs a nerve graft that does not often give acceptable recovery of facial function. Facial nerve schwannomas being a rare entity poses a dilemma in diagnosis and management. Managing the lesions is also difficult as intraoperative adherence to the nerve makes a tumour free margin difficult without sacrificing the nerve. At present there is no consensus regarding the management of various types of intra-parotid facial nerve shwannoma.

摘要

评估腮腺内面神经鞘瘤(IFNS)的临床流行病学特征、病理特征、诊断方法、治疗方案及功能预后,并报告一例腮腺内面神经鞘瘤病例。检索了PubMed、ProQuest、谷歌学术、Science direct和Scopus等数据库中的研究。由一名研究人员进行文章筛选和数据提取,另一名研究人员确认其准确性。根据PRISMA指南,经过摘要和文本筛选,最终共选择了69篇文章进行研究,并加上了我院报告的1例病例。诊断时的平均年龄为43±16岁,女性略占优势。肿瘤的平均病程为29.5个月,初诊时肿瘤的平均大小为3.6±1.67厘米。44例患者的初步诊断为多形性腺瘤。64例行浅叶腮腺切除术,47例行肿瘤切除术。3例患者采用端端吻合进行重建治疗,16例患者采用面-舌下神经吻合,5例患者采用GAN电缆移植,18例患者采用耳大神经移植,8例患者采用端侧插入腓肠神经移植。D型肿瘤采用面神经扩大切除术治疗,这种手术难以重建,且使用的神经移植往往无法使面部功能得到可接受的恢复。面神经鞘瘤是一种罕见的疾病,在诊断和治疗上存在两难境地。处理这些病变也很困难,因为术中紧贴神经会导致在不牺牲神经的情况下难以获得无瘤切缘。目前,对于各种类型的腮腺内面神经鞘瘤的治疗尚无共识。

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