重症肌无力中的琥珀酰胆碱。
Suxamethonium in myasthenia gravis.
作者信息
Wainwright A P, Brodrick P M
机构信息
National Hospital for Nervous Diseases, Queen Square, London.
出版信息
Anaesthesia. 1987 Sep;42(9):950-7. doi: 10.1111/j.1365-2044.1987.tb05365.x.
Abstract
The effects of suxamethonium 1.0 and 0.5 mg/kg were studied in myasthenic patients. Resistance was not encountered at the 1.0 mg/kg dose but was seen at the lower dose. A non-depolarising type of block developed in patients in both groups. However, recovery from the non-depolarising block was not prolonged beyond the requirements of surgery. The neurophysiological basis for, and clinical implications of these findings are discussed.
摘要
在重症肌无力患者中研究了1.0毫克/千克和0.5毫克/千克琥珀胆碱的效果。1.0毫克/千克剂量未出现耐药，但较低剂量时出现了耐药。两组患者均出现了非去极化型阻滞。然而，非去极化阻滞的恢复并未超过手术所需时间。讨论了这些发现的神经生理学基础及临床意义。
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