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肾移植吻合时间——分秒必争!

Renal transplant anastomotic time-Every minute counts!

作者信息

Mahajan Nikhil, Heer Munish K, Trevillian Paul R

机构信息

Newcastle Transplant Unit, Division of Surgery, John Hunter Hospital, New Lambton Heights, NSW, Australia.

Hunter Transplant Research Foundation, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.

出版信息

Front Med (Lausanne). 2023 Jan 18;9:1024137. doi: 10.3389/fmed.2022.1024137. eCollection 2022.

Abstract

The impact of anastomotic time in renal transplant is under recognized and not well studied. It is one of the few controllable factors that affect the incidence of delayed graft function (DGF). Our study aimed at quantifying the impact of anastomotic time. We performed a retrospective review of 424 renal transplants between the years 2006 and 2020. A total of 247 deceased donor renal transplants formed the study cohort. Patients were divided into two groups based on the presence or absence of DGF. Variables with < 0.3 were analyzed using the binary logistic regression test. The final analysis showed anastomotic time to be significantly associated with DGF with odds ratio of 1.04 per minute corresponding to 4% increase in DGF incidence with every minute increment in anastomotic time. Other variables that had significant impact on DGF were DCD donor (odds ratio - 8.7) and donor terminal creatinine. We concluded that anastomotic time had significant impact on the development of DGF and hence should be minimized.

摘要

肾移植中吻合时间的影响尚未得到充分认识,也未得到充分研究。它是影响移植肾功能延迟恢复(DGF)发生率的少数可控因素之一。我们的研究旨在量化吻合时间的影响。我们对2006年至2020年间的424例肾移植进行了回顾性研究。共有247例尸体供肾移植构成了研究队列。根据是否存在DGF将患者分为两组。对<0.3的变量使用二元逻辑回归检验进行分析。最终分析表明,吻合时间与DGF显著相关,每分钟的比值比为1.04,即吻合时间每增加一分钟,DGF发生率增加4%。对DGF有显著影响的其他变量是DCD供体(比值比 - 8.7)和供体终末肌酐。我们得出结论,吻合时间对DGF的发生有显著影响,因此应尽量缩短。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/304e/9889534/a5b97e8f535c/fmed-09-1024137-g001.jpg

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