β细胞研究的知识领域和新兴趋势：文献计量学和知识图谱分析。

BACKGROUND: Up to now, the physiology, pathology, and recovery of beta-cells have been intensively studied and made great progress, and these are of major significance for the treatment of related diseases. Nevertheless, a comprehensive and objective report on the status of beta-cell research is lacking. Therefore, this study aims to conduct a bibliometric analysis to quantify and identify the current status and trending issues in beta-cell research. METHODS: The articles and reviews related to beta-cell were obtained from the Web of Science Core Collection on August 31, 2022. Two scientometric software (CiteSpace 6.1.R3 and VOSviewer 1.6.18) were used to perform bibliometric and knowledge-map analysis. RESULTS: A total of 4098 papers were published in 810 academic journals in 2938 institutions from 83 countries/regions. The number of beta-cell-related publications was increasing steadily. The United States was the most productive country, while Universite libre de Bruxelles, University of Toronto and University of Geneva were the most active institutions. published the most beta-cell studies and received the largest number of co-citations. Decio I Eizirik published the most papers and had the most co-citations. Twelve references on reviews and mechanisms were regarded as the knowledge base. Four major aspects of beta-cell research included the pathological mechanism of beta-cell failure, the recovery of beta cells, the risk factor related to beta cells, and the physiology of beta cells. Endoplasmic reticulum stress and oxidative stress have been core elements throughout the research in this field. In addition, beta-cell dedifferentiation, inflammation, autophagy, miRNA, and lncRNA are hot topics nowadays. Additionally, stem cell replacement therapies might be the alternative way to reverse beta-cell failure. Restoring beta-cell mass and function will remain a research goal in the future. CONCLUSION: This study provided a comprehensive overview of beta-cell research through bibliometric and visual methods. The information would provide helpful references for scholars focusing on beta cells.

背景：迄今为止，β细胞的生理学、病理学和恢复已经得到了深入研究并取得了重大进展，这对相关疾病的治疗具有重要意义。然而，目前缺乏对β细胞研究现状的全面、客观的报告。因此，本研究旨在进行文献计量分析，以量化和确定β细胞研究的现状和趋势问题。

方法：于 2022 年 8 月 31 日从 Web of Science 核心合集获取与β细胞相关的文章和综述。使用两种科学计量软件（CiteSpace 6.1.R3 和 VOSviewer 1.6.18）进行文献计量和知识图谱分析。

结果：共发表在 810 种学术期刊上的 4098 篇论文来自 83 个国家/地区的 2938 个机构。β细胞相关出版物的数量呈稳步增长趋势。美国是最具生产力的国家，而布鲁塞尔自由大学、多伦多大学和日内瓦大学是最活跃的机构。发表了最多的β细胞研究，获得了最多的共被引。Decio I Eizirik 发表的论文最多，共被引也最多。12 篇关于综述和机制的参考文献被视为知识基础。β细胞研究的四个主要方面包括β细胞衰竭的病理机制、β细胞的恢复、与β细胞相关的风险因素以及β细胞的生理学。内质网应激和氧化应激一直是该领域研究的核心要素。此外，β细胞去分化、炎症、自噬、miRNA 和 lncRNA 是当前的热门话题。此外，干细胞替代疗法可能是逆转β细胞衰竭的替代方法。恢复β细胞的质量和功能将仍然是未来的研究目标。

结论：本研究通过文献计量学和可视化方法对β细胞研究进行了全面概述。这些信息将为关注β细胞的学者提供有价值的参考。