Pereira Guedes Tiago, Alves Silva Joana, Neves Sara, Falcão Daniela, Costa Paula, Lago Paula, Pedroto Isabel, Salgado Marta
Gastroenterology Department, Centro Hospitalar Universitário do Porto, Porto, Portugal.
Infectious Diseases Department, Centro Hospitalar Universitário do Porto, Porto, Portugal.
GE Port J Gastroenterol. 2021 Nov 25;30(1):20-28. doi: 10.1159/000520272. eCollection 2023 Jan.
are Gram-negative rods known to cause a spectrum of diseases. Inflammatory bowel disease (IBD) is an idiopathic complex condition resulting from interaction of multiple factors. Aeromonas infection in association with IBD is still largely unknown. We aim to look for the significance of infection and for significant differences between IBD and non-IBD patients.
A retrospective observational analysis was performed of all patients positive for in stool cultures, during a 10-year period, from a tertiary and university hospital.
Fifty patients were included, 56% male with a mean age of 42.1 years. Thirty-eight (76%) were non-IBD and 12 (24%) IBD patients. IBD patients were more frequently under immunosuppressors. Two patients were asymptomatic and 44% developed mild, 44% moderate, and 16.7% severe infection. The main strains isolated were . Bacterial co-isolation was found in 4 non-IBD and histological findings of cytomegalovirus in 2 IBD patients. Non-IBD patients presented more frequently with fever and IBD patients with bloody diarrhea and abdominal pain. There was higher tendency for severe infection rate in IBD patients with higher antimicrobial therapy use. Steroids were exclusively used in the IBD group. From IBD, 4 patients had the diagnosis of ulcerative colitis and 9 of Crohn's disease with colonic involvement. Of these patients, 5 received IBD diagnosis after the acute episode of infection.
Clinical presentation of infection differs between IBD and non-IBD patients. Non-IBD patients had milder severity of infection with less use of antibiotics. infection seems to greatly contribute to IBD manifestation.
革兰氏阴性杆菌可引发一系列疾病。炎症性肠病（IBD）是一种由多种因素相互作用导致的特发性复杂病症。气单胞菌感染与IBD的关联在很大程度上仍不明确。我们旨在探寻气单胞菌感染的意义以及IBD患者与非IBD患者之间的显著差异。
对一家三级大学医院10年间粪便培养中气单胞菌呈阳性的所有患者进行回顾性观察分析。
共纳入50例患者，男性占56%，平均年龄42.1岁。38例（76%）为非IBD患者，12例（24%）为IBD患者。IBD患者更常使用免疫抑制剂。2例患者无症状，44%发生轻度感染，44%为中度感染，16.7%为重度感染。分离出的主要菌株为……。4例非IBD患者存在细菌共分离现象，2例IBD患者有巨细胞病毒的组织学表现。非IBD患者发热更为常见，IBD患者则以血性腹泻和腹痛为主。IBD患者使用抗菌治疗较多时，严重感染率有更高的趋势。类固醇仅在IBD组使用。IBD患者中，4例诊断为溃疡性结肠炎，9例为克罗恩病累及结肠。其中，5例患者在气单胞菌感染急性发作后被诊断为IBD。
IBD患者与非IBD患者气单胞菌感染的临床表现有所不同。非IBD患者感染严重程度较轻，抗生素使用较少。气单胞菌感染似乎对IBD的表现有很大影响。
