Christian Michael, Long Bo, Tian Zhanglin, Dong Yuhan, Huang Junmeng, Wei Youdong
Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, CHN.
Cureus. 2023 Dec 10;15(12):e50297. doi: 10.7759/cureus.50297. eCollection 2023 Dec.
The expression of oncostatin M (OSM) has been studied in various diseases related to inflammatory response, but its implementation in acute ischemic stroke (AIS) remains to be explored. Objective: The objective of this study is to assess the correlation between serum OSM expression and various aspects of AIS in a clinical setting.
A single-centered case-control study was performed in the First Affiliate Hospital of Chongqing Medical University from October 2020 to March 2021. A total of 134 patients were enrolled in the AIS group and 34 healthy individuals were enrolled in the control group. Physical examinations were performed and venous blood samples were collected. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum OSM. Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification, National Institutes of Health Stroke Scale (NIHSS) score, magnetic resonance imaging (MRI) scan, and modified Rankin scale (mRS) were used to assess the classification, etiology, severity, and prognosis of the AIS group. Assessments were done to analyze serum OSM expression based on sensitivity, etiology, severity, prognosis, and several risk factors of AIS. Regression models, correlation, and sensitivity tests were performed to explore the correlation of OSM expression with various aspects of AIS.
There was a statistically significant elevation of serum OSM expression in the AIS group (P<0.001). All AIS subgroups showed elevation in OSM level and statistically significant results were reflected in three subgroups. The area under the curve to differentiate AIS patients and control by serum OSM level was 0.747 (P<0.001), with the optimal cut-off value showing sensitivity at 58.82% and specificity at 75.37%. The elevation of serum OSM expression was proportional with severity, not proportional to the volume of infarct, and less elevated in the favorable outcome group. Serum OSM correlation with several risk factors of AIS was statistically significant in age, low-density lipoprotein, non-high-density lipoprotein, prothrombin time, and systolic blood pressure.
Serum OSM was expressed differently in correlation with various aspects of AIS. Our findings supported the initial hypothesis that OSM is correlated with various aspects of AIS in humans.
抑瘤素M（OSM）在多种与炎症反应相关的疾病中的表达已得到研究，但其在急性缺血性卒中（AIS）中的作用仍有待探索。目的：本研究旨在评估临床环境中血清OSM表达与AIS各方面之间的相关性。
2020年10月至2021年3月在重庆医科大学附属第一医院进行了一项单中心病例对照研究。AIS组共纳入134例患者，对照组纳入34例健康个体。进行体格检查并采集静脉血样。采用酶联免疫吸附测定（ELISA）法检测血清OSM。采用急性卒中治疗中组织纤溶酶原激活物10172试验（TOAST）分类、美国国立卫生研究院卒中量表（NIHSS）评分、磁共振成像（MRI）扫描和改良Rankin量表（mRS）评估AIS组的分类、病因、严重程度和预后。基于AIS的敏感性、病因、严重程度、预后和几个危险因素对血清OSM表达进行评估分析。进行回归模型、相关性和敏感性检验以探讨OSM表达与AIS各方面的相关性。
AIS组血清OSM表达有统计学意义的升高（P<0.001）。所有AIS亚组的OSM水平均升高，三个亚组有统计学意义的结果。通过血清OSM水平区分AIS患者和对照组的曲线下面积为0.747（P<0.001），最佳截断值显示敏感性为58.82%，特异性为75.37%。血清OSM表达的升高与严重程度成正比，与梗死体积不成正比，在预后良好组中升高较少。血清OSM与AIS的几个危险因素在年龄、低密度脂蛋白、非高密度脂蛋白、凝血酶原时间和收缩压方面的相关性有统计学意义。
血清OSM在与AIS各方面的相关性中表达不同。我们的研究结果支持最初的假设，即OSM与人类AIS的各方面相关。
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