Department of Interventional Ultrasound, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Department of Ultrasound, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Clin Hemorheol Microcirc. 2023;83(4):377-386. doi: 10.3233/CH-221659.
The inadequacy samples caused by the internal characteristic structure of thyroid nodules are difficult to be solved.
To evaluate the ultrasound features affecting the sample adequacy after fine-needle aspiration (FNA) of thyroid nodules with different risk stratification.
592 thyroid nodules that underwent ultrasound-guided FNA were included in this retrospective study. The sample obtained by FNA were classified as inadequacy and adequacy according to the cytopathological results. Ultrasound features (ie., size, position, cystic predominance, composition, echo, shape, margin, and superficial annular calcification status) of the nodules were recorded and compared between the inadequacy sample group and adequacy sample group.
Multiple logistic regression shows that preponderant cystic proportion (OR, 0.384; P = 0.041), extremely hypoechogenicity and hypoechogenicity (OR, 6.349; P = 0.006) were the independent influencing factors of inadequate samples after FNA in benign expected nodules. In addition, nodule size ≤10 mm (OR, 1.960; P = 0.010) and superficially annular calcification (OR, 4.600; P < 0.001) were independent influencing factors for inadequate samples after FNA in malignant expected nodules.
The ultrasound features of hypoechogenicity or high cystic proportion in benign expected nodules and that of small size or annular calcification in malignant expected nodules were the risk factors for inadequacy samples by US-guided FNA.
甲状腺结节内部特征结构导致的不充分样本难以解决。
评估不同风险分层的甲状腺结节细针抽吸（FNA）后影响样本充分性的超声特征。
本回顾性研究纳入了 592 个接受超声引导 FNA 的甲状腺结节。根据细胞病理学结果，将 FNA 获得的样本分为不充分和充分。记录结节的超声特征（即大小、位置、囊性优势、成分、回声、形状、边界和表面环状钙化状态），并在不充分样本组和充分样本组之间进行比较。
多因素逻辑回归显示，在良性预期结节中，优势囊性比例（OR，0.384；P = 0.041）、极度低回声和低回声（OR，6.349；P = 0.006）是 FNA 后不充分样本的独立影响因素。此外，结节大小≤10 mm（OR，1.960；P = 0.010）和表面环状钙化（OR，4.600；P < 0.001）是恶性预期结节 FNA 后不充分样本的独立影响因素。
在良性预期结节中，超声表现为低回声或高囊性比例，在恶性预期结节中，超声表现为小尺寸或环状钙化，是 US 引导 FNA 不充分样本的危险因素。
