Kim Yoon Kook, Munir Kashif M, Davis Stephen N
Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Center for Diabetes and Endocrinology, 800 Linden Ave, 8th Floor, 21201, Baltimore, MD, USA.
Department of Medicine, University of Maryland School of Medicine, 22 South Greene Street, 21201, Baltimore, MD, USA.
Expert Opin Ther Targets. 2023 Jan;27(1):31-40. doi: 10.1080/14728222.2023.2177150. Epub 2023 Feb 13.
Despite significant strides made in the management of T1DM, standard management is still insulin analog therapy. Some non-insulin therapies traditionally reserved for the treatment of T2DM have been explored in caring for patients with T1DM, and pancreas transplant is an option for few. However, T1DM remains a challenging disease to manage, encouraging development of novel pharmacologic agents.
We retrieved PubMed, Cochrane Library, Scopus, Google Scholar, and ClinicalTrials.gov records to identify studies and articles focused on new pharmacologic advances to treat T1DM.
Recent research has focused on new targets of pharmacologic treatment of T1DM. Beta-cell preservation through immunomodulation or inhibiting inflammation hopes to delay or halt the progression of the disease. Beta cell regeneration through islet cell transplant or modification in transcription pathways aim to reverse the disease effects. Multiple other new targets such as glucagon antagonism and glucokinase activation are also in development as a potential adjunctive therapy. These new therapeutic targets offer the hope of reducing the daily burden of diabetes management with eventual insulin discontinuation for many individuals with T1DM.
尽管在1型糖尿病的管理方面取得了重大进展，但标准管理仍然是胰岛素类似物治疗。一些传统上用于治疗2型糖尿病的非胰岛素疗法已在1型糖尿病患者的护理中进行了探索，胰腺移植是少数患者的一种选择。然而，1型糖尿病仍然是一种难以管理的疾病，这促使新型药物的开发。
我们检索了PubMed、Cochrane图书馆、Scopus、谷歌学术和ClinicalTrials.gov记录，以识别专注于治疗1型糖尿病新药理学进展的研究和文章。
最近的研究集中在1型糖尿病药物治疗的新靶点上。通过免疫调节或抑制炎症来保护β细胞，希望延缓或阻止疾病的进展。通过胰岛细胞移植或转录途径修饰来实现β细胞再生，旨在逆转疾病影响。其他多个新靶点，如胰高血糖素拮抗和葡萄糖激酶激活，也在作为潜在的辅助治疗进行开发。这些新的治疗靶点有望减轻许多1型糖尿病患者日常糖尿病管理的负担，并最终停用胰岛素。
