Klinikum der Landeshauptstadt Stuttgart gKAöR, Olgahospital, Stuttgart Cancer Center, Zentrum für Kinder-, Jugend- und Frauenmedizin, Pädiatrie 5 (Pädiatrische Onkologie, Hämatologie, Immunologie), Stuttgart, Germany.
Medizinische Fakultät der Universität Tübingen, Tübingen, Germany.
Cancer Med. 2023 May;12(10):11719-11730. doi: 10.1002/cam4.5671. Epub 2023 Feb 6.
Margin status following surgery in children, adolescents, and young adults with soft tissue sarcomas is controversial and has been defined differently by various specialties, with definitions changing over time and by cooperative group. The International Soft Tissue Sarcoma Consortium (INSTRuCT) is a collaboration of the Children's Oncology Group (COG) Soft Tissue Sarcoma Committee, European pediatric Soft Tissue sarcoma Study Group (EpSSG), and the European Cooperative Weichteilsarkom Studiengruppe (CWS) devoted to improving patient outcomes by pooling and mining cooperative group clinical trial data.
The INSTRuCT non-rhabdomyosarcoma soft tissue sarcoma (NRSTS) working group aimed to develop international harmonized recommendations regarding surgical margin assessment and definitions in children and adolescents with soft tissue tumors.
This review addresses accepted principles and areas of controversy, including the perspectives of surgeons, pathologists, radiation oncologists, and pediatric oncologists, to develop a framework for building common guidelines for future research.
软组织肉瘤患儿、青少年和年轻成人手术后的切缘状态存在争议，不同专业对此有不同的定义，定义随着时间和合作组的变化而变化。国际软组织肉瘤联合会（INSTRuCT）是儿童肿瘤学组（COG）软组织肉瘤委员会、欧洲儿科软组织肉瘤研究组（EpSSG）和欧洲合作软组织肉瘤研究组（CWS）的合作，致力于通过汇集和挖掘合作组临床试验数据来改善患者的预后。
INSTRuCT 非横纹肌肉瘤软组织肉瘤（NRSTS）工作组旨在制定关于儿童和青少年软组织肿瘤手术切缘评估和定义的国际协调建议。
本综述探讨了公认的原则和有争议的领域，包括外科医生、病理学家、放射肿瘤学家和儿科肿瘤学家的观点，以制定一个框架，为未来的研究制定共同的指南。
