Komatsu H, Ogli K
Department of Anesthesiology and Emergency Medicine, Kagawa Medical School, Japan.
Anesthesiology. 1987 Nov;67(5):771-4. doi: 10.1097/00000542-198711000-00022.
Some strains of mice, in whom anesthesia was induced with 1.2% isoflurane in air, developed episodes of intense opisthotonus, lasting 1-2 min. Occasionally, opisthotonus also occurred transiently on emergence from isoflurane anesthesia. The incidence of opisthotonus upon anesthetic induction varied with the strain of mice studied, and was particularly high (nearly 80%) in the ddN and YBR/Ki strains. A significantly lower incidence of opisthotonus was observed in all 14 strains studied when 2.0% enflurane was used. One percent halothane did not produce opisthotonus in any strain of mice except one animal of the YBR/Ki strain, and, in this situation, it occurred only on emergence. These results suggest that, in some strains of mice, induction of anesthesia with isoflurane may apparently excite (disinhibit) the central nervous system more intensely than does anesthesia with enflurane or halothane.
一些小鼠品系，用含1.2%异氟烷的空气诱导麻醉后，会出现强烈的角弓反张发作，持续1至2分钟。偶尔，在异氟烷麻醉苏醒时也会短暂出现角弓反张。麻醉诱导时角弓反张的发生率因所研究的小鼠品系而异，在ddN和YBR/Ki品系中尤其高（近80%）。当使用2.0%恩氟烷时，在所研究的所有14个品系中观察到角弓反张的发生率显著降低。1%的氟烷在除一只YBR/Ki品系动物外的任何小鼠品系中均未产生角弓反张，而且在这种情况下，仅在苏醒时出现。这些结果表明，在一些小鼠品系中，异氟烷诱导麻醉可能比恩氟烷或氟烷诱导麻醉更明显地强烈兴奋（解除抑制）中枢神经系统。
