修复项目：一项研究自然本底辐射生物效应的深地放射生物学实验——头6年

The REPAIR Project, a Deep-Underground Radiobiology Experiment Investigating the Biological Effects of Natural Background Radiation: The First 6 Years.

作者信息

Pirkkanen Jake, Lalonde Christine, Lapointe Michel, Laframboise Taylor, Mendonca Marc S, Boreham Douglas R, Tharmalingam Sujeenthar, Thome Christopher

机构信息

School of Natural Sciences, Laurentian University, Sudbury, Ontario, P3E 2C6, Canada.

Department of Radiation Oncology, Radiation and Cancer Biology Laboratories, and Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202.

出版信息

Radiat Res. 2023 Mar 1;199(3):290-293. doi: 10.1667/RADE-22-00193.1.

DOI:10.1667/RADE-22-00193.1

PMID:36745561

Abstract

In 2017, a special edition of Radiation Research was published [Oct; Vol. 188 4.2 (https://bioone.org/journals/radiation-research/volume-188/issue-4.2)] which focused on a recently established radiobiology project within SNOLAB, a unique deep-underground research facility. This special edition included original articles, reviews and commentaries relevant to the research goals of this new project which was titled Researching the Effects of the Presence and Absence of Ionizing Radiation (REPAIR). These research goals were founded in understanding the biological effects of terrestrial and cosmic natural background radiation (NBR). Since 2017, REPAIR has evolved into a sub-NBR radiobiology research program which investigates these effects using multiple model systems and various biological endpoints. This paper summarizes the evolution of the REPAIR project over the first 6-years including its experimental scope and capabilities as well as research accomplishments.

摘要

2017年，《辐射研究》出版了一期特刊[10月；第188卷4.2期(https://bioone.org/journals/radiation-research/volume-188/issue-4.2)]，该特刊聚焦于SNOLAB（一个独特的地下深层研究设施）内最近设立的一个放射生物学项目。这期特刊包括与这个名为“研究电离辐射存在与不存在的影响（REPAIR）”的新项目研究目标相关的原创文章、综述和评论。这些研究目标基于对陆地和宇宙自然背景辐射（NBR）生物效应的理解。自2017年以来，REPAIR已发展成为一个亚NBR放射生物学研究项目，该项目使用多种模型系统和各种生物学终点来研究这些效应。本文总结了REPAIR项目头6年的发展历程，包括其实验范围和能力以及研究成果。