Computational and Systems Biology, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil.
Scientific Computing Program, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil.
PLoS One. 2023 Feb 6;18(2):e0272672. doi: 10.1371/journal.pone.0272672. eCollection 2023.
Sporotrichosis is a subcutaneous mycosis with a global distribution, also known as "rose gardener's disease". Brazil is experiencing a rapid spread of the zoonotic transmission of of Sporothrix brasiliensis, the main etiological agent of this disease in this country, affecting domestic felines. Cost-effective interventions need to be developed to control this emergent public health problem. To allow for the comparison of alternative control strategies, we propose in this paper, a mathematical model representing the transmission of S. brasiliensis among cats, stratified by age and sex. Analytical properties of the model are derived and simulations show possible strategies for reducing the endemic levels of the disease in the cat population, with a positive impact on human health. The scenarios included mass treatment of infected cats and mass implementation of contact reduction practices, such as neutering. The results indicate that mass treatment can reduce substantially the disease prevalence, and this effect is potentialized when combined with neutering or other contact-reduction interventions. On the other hand, contact-reduction methods alone are not sufficient to reduce prevalence.
孢子丝菌病是一种具有全球分布的皮下真菌感染，也被称为“玫瑰园工人病”。巴西正经历着由巴西分枝孢子菌引起的人畜共患病的快速传播，巴西分枝孢子菌是该国该病的主要病原体，影响家养猫科动物。需要开发具有成本效益的干预措施来控制这一突发的公共卫生问题。为了能够比较替代控制策略，我们在本文中提出了一个数学模型，该模型代表了猫科动物之间巴西分枝孢子菌的传播，按年龄和性别分层。推导出了模型的分析性质，模拟结果显示了减少猫群中疾病流行水平的可能策略，对人类健康产生积极影响。这些方案包括对感染猫进行大规模治疗和大规模实施减少接触的措施，如绝育。结果表明，大规模治疗可以显著降低疾病的流行率，而当与绝育或其他减少接触的干预措施结合使用时，这种效果会增强。另一方面，仅减少接触的方法不足以降低流行率。
