Department of Molecular Biology & Biochemistry, Simon Fraser University, Burnaby, BC, Canada.
Canada's Michael Smith Genome Sciences Centre at BC Cancer, Vancouver, BC, Canada.
Biochem Cell Biol. 2023 Apr 1;101(2):160-171. doi: 10.1139/bcb-2022-0332. Epub 2023 Feb 6.
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are among the most abundantly expressed RNA binding proteins in the cell and play major roles in all facets of RNA metabolism. hnRNPs are increasingly appreciated as essential for mammalian B cell development by regulating the carefully ordered expression of specific genes. Due to this tight regulation of the hnRNP-RNA network, it is no surprise that a growing number of genes encoding hnRNPs have been causally associated with the onset or progression of many cancers, including B cell neoplasms. Here we discuss our current understanding of hnRNP-driven regulation in normal, perturbed, and malignant B cells, and the most recent and emerging therapeutic innovations aimed at targeting the hnRNP-RNA network in lymphoma.
异质核核糖核蛋白（hnRNPs）是细胞中表达最丰富的 RNA 结合蛋白之一，在 RNA 代谢的各个方面发挥着重要作用。hnRNPs 通过调节特定基因的精心有序表达，被越来越多地认为是哺乳动物 B 细胞发育所必需的。由于 hnRNP-RNA 网络的这种紧密调节，越来越多编码 hnRNPs 的基因与许多癌症（包括 B 细胞肿瘤）的发生或进展有关，这并不奇怪。在这里，我们讨论我们对正常、失调和恶性 B 细胞中 hnRNP 驱动的调节的现有理解，以及最近和新兴的旨在靶向淋巴瘤中 hnRNP-RNA 网络的治疗创新。
