Key Laboratory of Animal Breeding and Healthy Livestock Farming, College of Animal Science and Veterinary Medicine, Tianjin Agricultural University, Tianjin 300392, China.
Biomolecules. 2023 Sep 22;13(10):1434. doi: 10.3390/biom13101434.
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a superfamily of RNA-binding proteins consisting of more than 20 members. These proteins play a crucial role in various biological processes by regulating RNA splicing, transcription, and translation through their binding to RNA. In the context of muscle development and regeneration, hnRNPs are involved in a wide range of regulatory mechanisms, including alternative splicing, transcription regulation, miRNA regulation, and mRNA stability regulation. Recent studies have also suggested a potential association between hnRNPs and muscle-related diseases. In this report, we provide an overview of our current understanding of how hnRNPs regulate RNA metabolism and emphasize the significance of the key members of the hnRNP family in muscle development. Furthermore, we explore the relationship between the hnRNP family and muscle-related diseases.
异质核核糖核蛋白（hnRNPs）是一个由超过 20 个成员组成的 RNA 结合蛋白超家族。这些蛋白质通过与 RNA 结合，在调节 RNA 剪接、转录和翻译等各种生物学过程中发挥着关键作用。在肌肉发育和再生方面，hnRNPs 参与了广泛的调控机制，包括可变剪接、转录调控、miRNA 调控和 mRNA 稳定性调控。最近的研究还表明 hnRNPs 与肌肉相关疾病之间存在潜在关联。在本报告中，我们概述了我们目前对 hnRNPs 如何调节 RNA 代谢的理解，并强调了 hnRNP 家族的关键成员在肌肉发育中的重要性。此外，我们还探讨了 hnRNP 家族与肌肉相关疾病之间的关系。
