Micheau C, Schwaab G, Vera Sempere F J, Llombart-Bosch A
Institut Gustave-Roussy, Villejuif.
Ann Otolaryngol Chir Cervicofac. 1987;104(4):251-7.
Ten cases of giant cell tumor of maxilla are reported, the patients being children or young adults and of principally female sex. In three cases another affection was associated: Recklinghausen's disease, Francescatti syndrome and hyperthyroidism of adenomatous origin. Histology of all tumors was similar: giant cells, fibroblastic tissue and numerous vessels: the course was benign in all cases with frequent recurrences but no metastases. The pathology of these tumors is still the subject of wide debate, although research is extensive in this field: electron microscopy, histoenzymology, monoclonal antibodies are some aspects studied but results have sofar failed to elucidate the true nature and histoprognosis of these tumors.
报告了10例上颌骨巨细胞瘤病例，患者为儿童或青年，主要为女性。3例伴有其他病症：冯雷克林霍增氏病、弗朗西斯科蒂综合征和腺瘤性甲状腺功能亢进。所有肿瘤的组织学表现相似：巨细胞、成纤维组织和大量血管；所有病例病程均为良性，虽频繁复发但无转移。尽管该领域研究广泛，包括电子显微镜检查、组织酶学、单克隆抗体等方面，但这些肿瘤的病理学仍存在广泛争议，迄今为止的研究结果未能阐明这些肿瘤的真正性质和组织预后。
