Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou510080, People's Republic of China.
Department of Experimental Research, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, 651 Dongfeng Road East, Guangzhou510060, People's Republic of China.
Br J Nutr. 2023 Oct 14;130(7):1239-1249. doi: 10.1017/S0007114523000351. Epub 2023 Feb 7.
Circulating -3 PUFA, which integrate endogenous and exogenous -3 PUFA, can be better used to investigate the relationship between -3 PUFA and disease. However, studies examining the associations between circulating -3 PUFA and colorectal cancer (CRC) risk were limited, and the results remained inconclusive. This case–control study aimed to examine the association between serum -3 PUFA and CRC risk in Chinese population. A total of 680 CRC cases and 680 sex- and age-matched (5-year interval) controls were included. Fatty acids were assayed by GC. OR and 95 % CI were calculated using multivariable logistic regression after adjustment for potential confounders. Higher level of serum α-linolenic acid (ALA), docosapentaenoic acid (DPA), DHA, long-chain -3 PUFA and total -3 PUFA were associated with lower odds of CRC. The adjusted OR and 95 % CI were 0·34 (0·24, 0·49, < 0·001) for ALA, 0·57 (0·40, 0·80, < 0·001) for DPA, 0·48 (0·34, 0·68, < 0·001) for DHA, 0·39 (0·27, 0·56, < 0·001) for long-chain -3 PUFA and 0·31 (0·22, 0·45, < 0·001) for total -3 PUFA comparing the highest with the lowest quartile. However, there was no statistically significant association between EPA and odds of CRC. Analysis stratified by sex showed that ALA, DHA, long-chain -3 PUFA and total -3 PUFA were inversely associated with odds of CRC in both sexes. This study indicated that serum ALA, DPA, DHA, long-chain -3 PUFA and total -3 PUFA were inversely associated with odds of having CRC in Chinese population.
循环 -3PUFA，整合了内源性和外源性 -3PUFA，可以更好地研究 -3PUFA 与疾病之间的关系。然而，研究循环 -3PUFA 与结直肠癌（CRC）风险之间的关联的研究有限，结果仍不确定。本病例对照研究旨在探讨中国人群血清 -3PUFA 与 CRC 风险之间的关系。共纳入 680 例 CRC 病例和 680 名性别和年龄匹配（5 年间隔）的对照。通过 GC 测定脂肪酸。在调整潜在混杂因素后，采用多变量 logistic 回归计算 OR 和 95%CI。血清 α-亚麻酸（ALA）、二十二碳五烯酸（DPA）、二十二碳六烯酸（DHA）、长链 -3PUFA 和总 -3PUFA 水平升高与 CRC 患病风险降低相关。调整后的 OR 和 95%CI 为 ALA：0.34（0.24，0.49，<0.001）、DPA：0.57（0.40，0.80，<0.001）、DHA：0.48（0.34，0.68，<0.001）、长链 -3PUFA：0.39（0.27，0.56，<0.001）、总 -3PUFA：0.31（0.22，0.45，<0.001），与最低四分位数相比，最高四分位数。然而，EPA 与 CRC 患病风险之间没有统计学显著关联。按性别分层分析显示，ALA、DHA、长链 -3PUFA 和总 -3PUFA 与男性和女性 CRC 患病风险呈负相关。本研究表明，中国人群血清 ALA、DPA、DHA、长链 -3PUFA 和总 -3PUFA 与 CRC 患病风险呈负相关。
