Tajik Behnam, Kurl Sudhir, Tuomainen Tomi-Pekka, Virtanen Jyrki K
Kuopio Campus,Institute of Public Health and Clinical Nutrition,University of Eastern Finland,70211 Kuopio,Finland.
Br J Nutr. 2016 Aug;116(3):487-95. doi: 10.1017/S0007114516002142. Epub 2016 Jun 3.
Long-chain n-3 PUFA from fish and exercise capacity are associated with CVD risk. Fish, especially large and old predatory fish, may contain Hg, which may attenuate the inverse association of long-chain n-3 PUFA with CVD. However, the associations of long-chain n-3 PUFA or Hg exposure with exercise capacity are not well known. We aimed to evaluate the associations of serum long-chain n-3 PUFA EPA, docosapentaenoic acid (DPA) and DHA and hair Hg with exercise cardiac power (ECP, a ratio of VO2max:maximal systolic blood pressure (SBP) during an exercise test), a measure for exercise capacity. For this, data from the population-based Kuopio Ischaemic Heart Disease Risk Factor Study were analysed cross-sectionally in order to determine the associations between serum long-chain n-3 PUFA, hair Hg and ECP in 1672 men without CVD, aged 42-60 years. After multivariate adjustments, serum total long-chain n-3 PUFA concentration was associated with higher ECP and VO2max (P trend across quartiles=0·04 and P trend=0·02, respectively), but not with maximal SBP (P trend=0·69). Associations were generally similar when EPA, DPA and DHA were evaluated individually. Hair Hg was not associated with ECP, VO2max or maximal SBP. However, the associations of total long-chain n-3 PUFA (P interaction=0·03) and EPA (P interaction=0·02) with higher VO2max were stronger among men with lower hair Hg. Higher serum long-chain n-3 PUFA concentration, mainly a marker for fish consumption in this study population, was associated with higher ECP and VO2max in middle-aged men from eastern Finland.
鱼类中的长链n-3多不饱和脂肪酸（PUFA）与运动能力和心血管疾病（CVD）风险相关。鱼类，尤其是大型老龄掠食性鱼类，可能含有汞，这可能会削弱长链n-3 PUFA与CVD之间的负相关关系。然而，长链n-3 PUFA或汞暴露与运动能力之间的关联尚不清楚。我们旨在评估血清长链n-3 PUFA二十碳五烯酸（EPA）、二十二碳五烯酸（DPA）和二十二碳六烯酸（DHA）以及头发汞含量与运动心功能（ECP，运动试验期间最大摄氧量与最大收缩压（SBP）的比值）之间的关联，ECP是运动能力的一项指标。为此，对基于人群的库奥皮奥缺血性心脏病危险因素研究中的数据进行了横断面分析，以确定1672名年龄在42至60岁之间无CVD的男性血清长链n-3 PUFA、头发汞含量与ECP之间的关联。经过多变量调整后，血清总长链n-3 PUFA浓度与较高的ECP和最大摄氧量相关（四分位数间P趋势分别为=0·04和P趋势=0·02），但与最大SBP无关（P趋势=0·69）。单独评估EPA、DPA和DHA时，关联通常相似。头发汞含量与ECP、最大摄氧量或最大SBP无关。然而，在头发汞含量较低的男性中，总长链n-3 PUFA（P交互作用=0·03）和EPA（P交互作用=0·02）与较高最大摄氧量之间的关联更强。在芬兰东部的中年男性中，较高的血清长链n-3 PUFA浓度（在本研究人群中主要是鱼类消费的标志物）与较高的ECP和最大摄氧量相关。
