Department of Haematology-Oncology, National University Cancer Institute, Singapore, National University Health System, Singapore, Singapore.
Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Br J Cancer. 2023 Apr;128(8):1415-1417. doi: 10.1038/s41416-023-02181-6. Epub 2023 Feb 6.
In an attempt to overcome resistance to immune checkpoint inhibitors (ICI), an ever-increasing number of trials are exploring combination treatment approaches. Outcomes of a novel ICI doublet presented by Desai and colleagues are discussed along with emerging novel strategies and a view to future ongoing rational trial design maximising patient benefit.
为了克服对免疫检查点抑制剂(ICI)的耐药性,越来越多的试验正在探索联合治疗方法。Desai 及其同事提出的一种新型 ICI 双药治疗方案的结果,以及新出现的策略和未来正在进行的合理试验设计的观点,都旨在最大限度地提高患者的获益。