Lim Cynthia Ciwei, Mok Irene Y J, Leeu Jun Jie, Liew Zhong Hong, Tan Hui Zhuan, Chin Yok Mooi, Teng Wei Ling, Yeo Fiona, Tan Chieh Suai, Choo Jason C J
Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore.
Lee Kong Chian School of Medicine, National Technological University, Singapore, Singapore.
Glomerular Dis. 2022 Jan 24;2(3):132-138. doi: 10.1159/000522158. eCollection 2022 Jul.
Shared decision-making regarding COVID-19 vaccination in IgA nephropathy involves the ability to handle health information regarding potential benefits and risk of flare, but few studies have evaluated health literacy in the context of vaccination. We aimed to evaluate the health literacy and COVID-19 vaccination uptake and acceptance in IgA nephropathy.
Single-center cross-sectional study of 126 consecutive patients with IgA nephropathy. Health literacy was assessed using the HLS-EU-47 questionnaire. Determinants of vaccine acceptance such as contextual influences, individual and group influences, and vaccine-specific issues were adapted from the World Health Organization framework.
Forty-eight patients (38.1%) with IgAN nephropathy completed the survey between June and August 2021. The participants' median age was 40.5 (31.6, 52.8) years with median disease duration of 2.8 (1.3, 4.3) years. The median general health literacy index was 31.74 (29.88, 35.82) with significantly greater difficulty in the competency of appraising health information and in the domain of disease prevention ( < 0.001). Forty-five patients (93.8%) received at least one dose of COVID-19 vaccine between January and August 2021. Among the 3 unvaccinated patients, 2 intended to receive the vaccination while and 1 did not intend to get vaccinated. There was a high level of trust and belief that their government and healthcare providers had their best interests at heart and that the healthcare providers were honest about the vaccine's risk and benefits, although 31.2% did not understand how the vaccine works and 22.9% believed that there were other ways to prevent infection. Most thought there was adequate safety information, were confident in the system for tracking adverse events and had no issues with access to the vaccine.
Participants with IgA nephropathy had high health literacy scores and low vaccine hesitancy. The determinants for vaccine acceptance can potentially guide efforts to optimize vaccination coverage.
IgA 肾病患者关于 COVID-19 疫苗接种的共同决策涉及处理有关疾病发作潜在益处和风险的健康信息的能力，但很少有研究在疫苗接种背景下评估健康素养。我们旨在评估 IgA 肾病患者的健康素养以及 COVID-19 疫苗接种率和接受度。
对 126 例连续的 IgA 肾病患者进行单中心横断面研究。使用 HLS-EU-47 问卷评估健康素养。疫苗接受度的决定因素，如背景影响、个人和群体影响以及疫苗特定问题，是根据世界卫生组织的框架改编的。
48 例 IgAN 肾病患者（38.1%）于 2021 年 6 月至 8 月期间完成了调查。参与者的中位年龄为 40.5（31.6，52.8）岁，中位病程为 2.8（1.3，4.3）年。总体健康素养指数中位数为 31.74（29.88，35.82），在评估健康信息的能力和疾病预防领域存在明显更大的困难（<0.001）。45 例患者（93.8%）在 2021 年 1 月至 8 月期间接种了至少一剂 COVID-19 疫苗。在 3 例未接种疫苗的患者中，2 例打算接种，1 例不打算接种。尽管 31.2%的人不了解疫苗的作用方式，22.9%的人认为有其他预防感染的方法，但他们高度信任并相信政府和医疗服务提供者是真心为他们着想的，并且医疗服务提供者对疫苗的风险和益处是诚实的。大多数人认为有足够的安全信息，对不良事件跟踪系统有信心，并且在获取疫苗方面没有问题。
IgA 肾病患者的健康素养得分较高，疫苗犹豫程度较低。疫苗接受度的决定因素可能有助于指导优化疫苗接种覆盖率的工作。
