黏菌素（多黏菌素E）的抗分枝杆菌谱
Antimycobacterial spectrum of colistin (polymixin E).
作者信息
Rastogi N, Potar M C, David H L
机构信息
Département de Bactériologie et Mycologie, Institut Pasteur, Paris.
出版信息
Ann Inst Pasteur Microbiol (1985). 1986 Jan-Feb;137A(1):45-53. doi: 10.1016/s0769-2609(86)80004-7.
Minimal inhibitory concentrations and minimal bactericidal concentrations of colistin (polymyxin E) were determined for the type strains of fifteen mycobacterial species. Colistin was found to be active against pathogenic species Mycobacterium xenopi, M. intracellulare, M. tuberculosis, M. fortuitum and also against the rapidly growing, non-pathogenic species M. phlei and M. smegmatis. The discriminatory potential of susceptibility to colistin as a test was investigated on 25 strains of the M. fortuitum/M. chelonei complex, and also on 11 strains of the M. avium/M. intracellulare complex. The experimental data indicated the potential of colistin susceptibility testing for discriminating M. fortuitum from M. chelonei.
测定了15种分枝杆菌菌株对黏菌素（多黏菌素E）的最低抑菌浓度和最低杀菌浓度。发现黏菌素对致病性分枝杆菌物种，如偶发分枝杆菌、胞内分枝杆菌、结核分枝杆菌、龟分枝杆菌有活性，也对快速生长的非致病性物种草分枝杆菌和耻垢分枝杆菌有活性。在25株龟分枝杆菌/偶然分枝杆菌复合群菌株以及11株鸟分枝杆菌/胞内分枝杆菌复合群菌株上研究了黏菌素药敏试验作为一种检测方法的鉴别潜力。实验数据表明黏菌素药敏试验有鉴别龟分枝杆菌和偶然分枝杆菌的潜力。
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