Gilman S, Dauth G W, Frey K A, Penney J B
Department of Neurology, University of Michigan Medical School, Ann Arbor 48109.
Ann Neurol. 1987 Sep;22(3):370-6. doi: 10.1002/ana.410220314.
Unilateral ablation of cerebral cortical areas 4 and 6 of Brodmann in the macaque monkey results in a dense contralateral hemiplegia that recovers partially with time. During the phase of dense hemiplegia, the local cerebral metabolic rate for glucose (lCMRGlc) is decreased significantly in the caudate nucleus, putamen, globus pallidus, subthalamic nucleus, substantia nigra, and red nucleus of the hemisphere ipsilateral to the lesion. In the present study, lCMRGlc in the basal ganglia was studied during the phase of partial recovery of motor activity. lCMRGlc was partially restored, and the greatest degree of restoration occurred in structures with direct connections to the cerebral cortex (caudate nucleus, putamen, subthalamic nucleus, substantia nigra, and red nucleus). Restoration was least in structures that do not receive direct connections from the cerebral cortex (the internal and external segments of the globus pallidus). The findings support the hypothesis that corticofugal activity accounts for a substantial degree of functional recovery.
对猕猴大脑布罗德曼4区和6区进行单侧切除，会导致严重的对侧偏瘫，随着时间推移会部分恢复。在严重偏瘫阶段，病变同侧半球的尾状核、壳核、苍白球、丘脑底核、黑质和红核中的局部脑葡萄糖代谢率（lCMRGlc）显著降低。在本研究中，对运动活动部分恢复阶段基底神经节中的lCMRGlc进行了研究。lCMRGlc部分恢复，恢复程度最大的是与大脑皮层有直接联系的结构（尾状核、壳核、丘脑底核、黑质和红核）。在未接受大脑皮层直接联系的结构（苍白球的内、外段）中恢复最少。这些发现支持了皮质传出活动在很大程度上促成功能恢复这一假说。
