A Better Start National Science Challenge, Liggins Institute, University of Auckland, Auckland, New Zealand.
Department of Women's and Children's Health, University of Otago, Dunedin, New Zealand.
Aust N Z J Psychiatry. 2023 Aug;57(8):1140-1149. doi: 10.1177/00048674231151606. Epub 2023 Feb 6.
Models of psychometric screening to identify individuals with neurodevelopmental disabilities (NDDs) have had limited success. In Aotearoa/New Zealand, routine developmental surveillance of preschool children is undertaken using the Before School Check (B4SC), which includes psychometric and physical health screening instruments. This study aimed to determine whether combining multiple screening measures could improve the prediction of NDDs.
Linked administrative health data were used to identify NDDs, including attention deficit hyperactivity disorder, autism spectrum disorder and intellectual disability, within a multi-year national cohort of children who undertook the B4SC. Cox proportional hazards models, with different combinations of potential predictors, were used to predict onset of a NDD. Harrell's c-statistic for composite models were compared with a model representing recommended cutoff psychometric scores for referral in New Zealand.
Data were examined for 287,754 children, and NDDs were identified in 10,953 (3.8%). The best-performing composite model combining the Strengths and Difficulties Questionnaire, the Parental Evaluation of Developmental Status, vision screening and biological sex had 'excellent' predictive power (C-statistic: 0.83) compared with existing referral pathways which had 'poor' predictive power (C-statistic: 0.68). In addition, the composite model was able to improve the sensitivity of NDD diagnosis detection by 13% without any reduction in specificity.
Combination of B4SC screening measures using composite modelling could lead to significantly improved identification of preschool children with NDDs when compared with surveillance that rely on individual psychometric test results alone. This may optimise access to academic, personal and family support for children with NDDs.
用于识别神经发育障碍(NDD)个体的心理计量筛查模型的效果有限。在新西兰,使用学前检查(B4SC)对学龄前儿童进行常规发育监测,其中包括心理计量和身体健康筛查工具。本研究旨在确定是否可以结合多种筛查措施来提高 NDD 的预测能力。
使用链接的行政健康数据,在参加 B4SC 的多年全国儿童队列中确定了 NDD,包括注意力缺陷多动障碍、自闭症谱系障碍和智力残疾。使用 Cox 比例风险模型,结合不同的潜在预测因素组合,预测 NDD 的发病。复合模型的 Harrell's c 统计量与新西兰推荐的转诊心理计量评分临界值模型进行了比较。
对 287754 名儿童的数据进行了检查,有 10953 名(3.8%)儿童患有 NDD。将儿童困难量表、父母发育状况评估、视力筛查和生物性别相结合的最佳表现复合模型具有“优秀”的预测能力(C 统计量:0.83),而现有的转诊途径的预测能力为“较差”(C 统计量:0.68)。此外,复合模型还可以将 NDD 诊断检测的敏感性提高 13%,而特异性没有任何降低。
与仅依靠个别心理计量测试结果的监测相比,使用 B4SC 筛查措施的组合进行复合建模可以显著提高对学龄前 NDD 儿童的识别能力。这可能会优化对 NDD 儿童的学术、个人和家庭支持的获取。