Department of Chemistry, Institute of Molecular Aggregation Science, Tianjin University, Tianjin, 300072, P. R. China.
Chembiochem. 2023 Apr 17;24(8):e202200777. doi: 10.1002/cbic.202200777. Epub 2023 Mar 22.
The development of fluorophores with other powerful features has received much attention for the diagnosis and treatment of diseases. Nanoprobes (NPs) with aggregation-induced emission (AIE) have demonstrated superior performance in deeper penetration depth with better resolution, higher signal-to-noise ratio, and lower side effects in the second near-infrared window (NIR-II, 1000-1700 nm) than in any other range. Herein, the latest advances in NIR-II AIE NPs in cancer theranostics are summarized. In particular, we focus on the design of multifunctional AIE agents with both strong NIR-II emission and effective photothermal conversion or reactive oxygen species (ROS) production, as well as their translational biomedical applications, including imaging diagnosis, image-guided surgery, and image-guided phototherapy, etc. At the end of this review, the opportunities and challenges of this field are also discussed.
具有其他强大特性的荧光团的发展受到了广泛关注，可用于疾病的诊断和治疗。具有聚集诱导发射（AIE）特性的纳米探针（NPs）在第二近红外窗口（NIR-II，1000-1700nm）中具有比其他任何区域都更深的穿透深度、更好的分辨率、更高的信噪比和更低的副作用，性能更优。本文总结了用于癌症诊治的近红外二区 AIE NPs 的最新进展。特别地，我们重点介绍了具有强近红外二区发射和有效光热转换或活性氧（ROS）产生功能的多功能 AIE 试剂的设计，以及它们在成像诊断、影像引导手术和影像引导光疗等转化医学应用。在这篇综述的最后，还讨论了该领域的机遇和挑战。
