College of Material, Chemistry and Chemical Engineering, Key Laboratory of Organosilicon Chemistry and Material Technology, Ministry of Education, Key Laboratory of Organosilicon Material Technology, Hangzhou Normal University, Zhejiang Province, Hangzhou, 311121, PR China.
State Key Laboratory of Chemical Engineering, Stoddart Institute of Molecular Science, Department of Chemistry, Zhejiang University, Hangzhou, 310027, PR China; ZJU-Hangzhou Global Scientific and Technological Innovation Center, Hangzhou, 311215, PR China; Green Catalysis Center and College of Chemistry, Zhengzhou University, Zhengzhou, 450001, PR China.
Biomaterials. 2022 Jun;285:121535. doi: 10.1016/j.biomaterials.2022.121535. Epub 2022 Apr 23.
As one of the major public health concerns, malignant tumors threaten people's lives. With the increasing demand for early accurate diagnosis and the safe treatment of tumors, non-invasive optical imaging (including fluorescence imaging and photoacoustic imaging) and phototherapy (including photothermal therapy and photodynamic therapy) have received much attention. In particular, light in the near-infrared second region (NIR-II) has been attracting research interest, owing to its deep penetration, minimal tissue autofluorescence, and decreased tissue absorption and scattering. Among all biological materials, organic nanomaterials with aggregation-induced emission (AIE) properties have attracted significant attention, owing to various incomparable advantages, such as high brightness, good photostability, tunable photophysical properties, and good biosafety. To modulate the working optical region of AIE molecules to the NIR-II region, many researchers have tried a variety of methods in recent years, and the focus of this review is to summarize the three most common methods from the perspective of molecular design strategies. In addition, this article briefly reviews the recent five-year progress of NIR-II AIE luminophores in tumor imaging and phototherapy applications. The research status is also summarized and prospected, with the hope of contributing to further research.
作为主要的公共卫生问题之一，恶性肿瘤威胁着人们的生命。随着对肿瘤早期准确诊断和安全治疗的需求不断增加，非侵入性光学成像（包括荧光成像和光声成像）和光疗（包括光热疗法和光动力疗法）受到了广泛关注。特别是近红外二区（NIR-II）的光由于其具有深穿透、最小的组织自发荧光、减少的组织吸收和散射，因此引起了研究兴趣。在所有生物材料中，具有聚集诱导发射（AIE）性质的有机纳米材料引起了人们的极大关注，因为它具有各种无与伦比的优势，例如高亮度、良好的光稳定性、可调的光物理性质和良好的生物安全性。为了将 AIE 分子的工作光学区域调谐到 NIR-II 区域，近年来许多研究人员尝试了多种方法，本文主要从分子设计策略的角度综述了三种最常见的方法。此外，本文还简要回顾了近五年来 NIR-II AIE 发光体在肿瘤成像和光疗应用中的最新进展。并对研究现状进行了总结和展望，希望对进一步的研究有所贡献。
