Center for Research in Perinatal and Reproductive Medicine, University of Perugia, Perugia, Italy.
Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
Int J Gynaecol Obstet. 2023 Jul;162(1):39-50. doi: 10.1002/ijgo.14714. Epub 2023 Feb 24.
Maternal influenza vaccination has been introduced in several countries to prevent influenza-related morbidity and mortality in pregnant women, fetuses, and infants too young to be vaccinated.
To analyze the available randomized controlled trials (RCTs) on the effectiveness of pregnant women-focused interventions to increase influenza vaccination uptake during pregnancy.
Medline, CINAHL, Scopus, Web of Science, and Cochrane Trial were searched on August 25, 2021.
RCTs assessing the effectiveness of pregnant women-focused interventions in increasing influenza vaccination among pregnant women were included.
Two independent reviewers extracted data. A random-effects meta-analysis was conducted to estimate pooled odds ratios (ORs).
Seven RCTs were selected. Overall, the interventions had a significant effect in increasing influenza vaccination during pregnancy compared with standard care (OR 1.78, 95% confidence interval [CI] 1.25-2.54; P = 0.001; I = 67%). However, subgroup analysis suggested that influenza vaccination uptake only was associated with educational interventions (OR 2.71, 95% CI 1.93-3.81; P < 0.001; I = 0%).
We found that several educational interventions for pregnant women can effectively increase influenza vaccination uptake in this population. Specifically, pamphlets, websites, and brief one-to-one education can be effective tools.
CRD42021269478.
为了预防孕妇、胎儿和因年龄太小而无法接种疫苗的婴儿罹患流感相关疾病和死亡，一些国家已经开始为孕妇接种流感疫苗。
分析旨在提高孕妇流感疫苗接种率的以孕妇为重点的干预措施的有效性的现有随机对照试验（RCT）。
于 2021 年 8 月 25 日检索了 Medline、CINAHL、Scopus、Web of Science 和 Cochrane 试验数据库。
评估以孕妇为重点的干预措施在提高孕妇流感疫苗接种率方面有效性的 RCT 纳入研究。
两位独立的评审员提取数据。采用随机效应荟萃分析来估计汇总优势比（OR）。
纳入了 7 项 RCT。总体而言，与标准护理相比，干预措施在增加怀孕期间的流感疫苗接种方面具有显著效果（OR 1.78，95%置信区间 [CI] 1.25-2.54；P = 0.001；I ² = 67%）。然而，亚组分析表明，仅流感疫苗接种与教育干预措施相关（OR 2.71，95% CI 1.93-3.81；P < 0.001；I ² = 0%）。
我们发现，针对孕妇的几种教育干预措施可以有效地提高该人群的流感疫苗接种率。具体而言，宣传册、网站和简短的一对一教育可能是有效的工具。
CRD42021269478。
