Bapat Anjaneya, Lucey Olivia, Eckersley Martyn, Ciesielczuk Holly, Ranasinghe Sherika, Lambourne Jonathan
Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Division of Infection, Barts Health NHS Trust, London, UK.
J Med Microbiol. 2022 Dec;71(12). doi: 10.1099/jmm.0.001612.
are Gram-negative, facultatively anaerobic rods or coccobacilli that are infrequently encountered as pathogens causing infection. The range of invasive infection that cause is poorly described. The pathogenicity of species such as is debated. To identify invasive infection due to species in a large healthcare organization and to characterize clinical syndromes, co-morbidities and risk factors. All microbiological samples positive for species were identified by conventional culture or 16S rRNA PCR between October 2017 and March 2021. Electronic records for all patients with positive samples were reviewed and the infection syndrome classified for patients with invasive disease. Twenty-seven patients with invasive infection were identified, with a statistically significant difference in species-specific patterns of invasive infection (=0.02) and a statistically significant association with residence in the 30 % most deprived households in the UK by postcode (<0.01). The three most common co-morbidities were periodontitis or recent dental work (29.6%), cardiovascular disease (25.9%) and diabetes (18.5 %). We describe a novel association of with skin and soft tissue infection. The propensity of the species to cause invasive infection at different body sites and be associated with deprivation is reported. bacteraemia was associated with infective endocarditis, and was implicated in severe appendicitis and noted to cause brain abscess. Areas warranting future research include exploring the risk-factors required for invasive infection and those that may determine the species-specific differences in patterns of invasive disease.
是革兰氏阴性、兼性厌氧杆菌或球杆菌，作为引起感染的病原体很少见。其引起的侵袭性感染范围描述不佳。诸如等物种的致病性存在争议。为了在一家大型医疗机构中识别由物种引起的侵袭性感染，并对临床综合征、合并症和风险因素进行特征描述。2017年10月至2021年3月期间，通过传统培养或16S rRNA PCR鉴定了所有对物种呈阳性的微生物样本。对所有样本呈阳性的患者的电子记录进行了审查，并对侵袭性疾病患者的感染综合征进行了分类。确定了27例侵袭性感染患者，侵袭性感染的物种特异性模式存在统计学显著差异（=0.02），并且与英国邮政编码显示的最贫困的30%家庭中的居住情况存在统计学显著关联（<0.01）。三种最常见的合并症是牙周炎或近期牙科治疗（29.6%）、心血管疾病（25.9%）和糖尿病（18.5%）。我们描述了与皮肤和软组织感染的一种新关联。报告了物种在不同身体部位引起侵袭性感染并与贫困相关的倾向。菌血症与感染性心内膜炎有关，并且与严重阑尾炎有关，还被指出可引起脑脓肿。值得未来研究的领域包括探索侵袭性感染所需的风险因素以及那些可能决定侵袭性疾病模式中物种特异性差异的因素。
