School of Cellular and Molecular Medicine, University of Bristol, Bristol, UK.
Department of Biological Sciences, University of Jeddah, Jeddah, Saudi Arabia.
Microbiology (Reading). 2023 Jan;169(1). doi: 10.1099/mic.0.001277.
In recent work we identified genes that confer the slow-growing and antibiotic-resistant small-colony variant (SCV) form of , as associated with the amount of capsule the bacteria produce. In this study we isolated a triclosan-resistant SCV (tr-SCV) and demonstrated that it produces significantly less capsule, an effect that appears to be mediated at the transcriptional stage. As with other SCVs, we found that the tr-SCV produces less toxins, and when compared to both a capsule and an Agr mutant we found the tr-SCV to be significantly attenuated in an insect model of infection.
在最近的工作中，我们确定了与细菌产生荚膜量相关的能够赋予 缓慢生长和抗抗生素的小菌落变异体 (SCV) 形式的基因。在这项研究中，我们分离出了一种三氯生抗性 SCV (tr-SCV)，并证明它产生的荚膜明显减少，这种效应似乎是在转录阶段介导的。与其他 SCVs 一样，我们发现 tr-SCV 产生的毒素较少，并且与荚膜和 Agr 突变体相比，我们发现 tr-SCV 在感染昆虫模型中明显减弱。
