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新冠病毒核磁共振联合研究团队:关于这一新型全球合作影响的公开报告。

The COVID19-NMR Consortium: A Public Report on the Impact of this New Global Collaboration.

作者信息

Duchardt-Ferner Elke, Ferner Jan, Fürtig Boris, Hengesbach Martin, Richter Christian, Schlundt Andreas, Sreeramulu Sridhar, Wacker Anna, Weigand Julia E, Wirmer-Bartoschek Julia, Schwalbe Harald

机构信息

Institute for Biomolecular Sciences, Center for Biomolecular Magnetic Resonance (BMRZ), Goethe-University Frankfurt, Max-von-Laue-Str. 9, 60438, Frankfurt/M., Germany.

Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Goethe-University Frankfurt, Max-von-Laue-Str. 7, 60438, Frankfurt/M., Germany.

出版信息

Angew Chem Int Ed Engl. 2023 Mar 27;62(14):e202217171. doi: 10.1002/anie.202217171. Epub 2023 Feb 7.

Abstract

The outbreak of COVID-19 in December 2019 required the formation of international consortia for a coordinated scientific effort to understand and combat the virus. In this Viewpoint Article, we discuss how the NMR community has gathered to investigate the genome and proteome of SARS-CoV-2 and tested them for binding to low-molecular-weight binders. External factors including extended lockdowns due to the global pandemic character of the viral infection triggered the transition from locally focused collaborative research conducted within individual research groups to digital exchange formats for immediate discussion of unpublished results and data analysis, sample sharing, and coordinated research between more than 50 groups from 18 countries simultaneously. We discuss key lessons that might pertain after the end of the pandemic and challenges that we need to address.

摘要

2019年12月新型冠状病毒肺炎(COVID-19)的爆发促使国际联盟的形成,以便开展协调一致的科学工作来了解和对抗这种病毒。在这篇观点文章中,我们讨论了核磁共振(NMR)领域是如何聚集起来研究严重急性呼吸综合征冠状病毒2(SARS-CoV-2)的基因组和蛋白质组,并测试它们与低分子量结合剂的结合情况。包括由于病毒感染的全球大流行特征而延长封锁等外部因素,引发了从各个研究小组内部进行的以本地为重点的合作研究,向数字交流形式的转变,以便立即讨论未发表的结果和数据分析、样本共享以及来自18个国家的50多个小组之间的协调研究。我们讨论了大流行结束后可能适用的关键经验教训以及我们需要应对的挑战。

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