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非综合征性腭裂修补术后患者行腭咽功能不全(VPD)手术治疗后的言语结局。

Speech Outcomes Following Operative Management of Velopharyngeal Dysfunction (VPD) in Non-Syndromic Post-Palatoplasty Cleft Palate Patients.

机构信息

Division of Plastic and Reconstructive Surgery, Stony Brook Medicine, Stony Brook, NY, USA.

Division of Reconstructive and Plastic Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

出版信息

Cleft Palate Craniofac J. 2024 Jun;61(6):1007-1017. doi: 10.1177/10556656231154808. Epub 2023 Feb 7.

Abstract

OBJECTIVE

Approximately 30% of patients with a history of repaired cleft palate (CP) go on to suffer from velopharyngeal dysfunction (VPD). This study discusses the operative management of VPD and postoperative speech outcomes in a cohort of CP patients.

SETTING

An academic tertiary pediatric care center.

METHODS

Retrospective cohort study.

PATIENTS

Patients with history of repaired CP (Veau I-IV) who underwent operative management of VPD between January 1st, 2010 and December 31st, 2020. Operative modalities were posterior pharyngeal flap (PPF), sphincter pharyngoplasty (SPP), Furlow palate re-repair, and buccal myomucosal flap palate lengthening (PL).

OUTCOME MEASURES

The primary outcome measure is postoperative speech improvement evaluated by the Pittsburgh Weighted Speech Scale (PWSS).

RESULTS

97 patients met inclusion criteria. 38 patients with previous straight-line primary palatoplasty underwent Furlow re-repair; these patients were significantly younger (7.62 vs 11.14,  < .001) and were more likely to have severe VPD per PWSS (OR 4.28,  < .01, 95% CI 1.46-12.56) when compared to VPD patients with previous Furlow repair. 21.1% of these patients required an additional non-revisional VPD procedure. The remaining patients underwent a non-revision procedure (26 PPF, 22 SPP, 11 PL); all experienced significant ( < .001 on paired t-test) reductions in PWSS total and subgroup VPD severity scores without difference in improvement between operation types. SPP was statistically associated with all-cause complication (OR 2.79, 95% CI 1.03-7.59,  < .05) and hyponasality (OR 3.27, 95% CI 1.112-9.630,  < .05).

CONCLUSION

Furlow re-repair reduced need for additional VPD operations. Speech outcomes between non-revisional operations are comparable, but increased complications were seen in SPP.

摘要

目的

约 30%的腭裂修补术后患者(CP)会出现咽腔闭合功能不全(VPD)。本研究讨论了一组 CP 患者 VPD 的手术治疗及术后语音效果。

设置

学术性三级儿科护理中心。

方法

回顾性队列研究。

患者

2010 年 1 月 1 日至 2020 年 12 月 31 日期间,行 VPD 手术治疗的 CP 病史患者(Veau I-IV 级)。手术方式包括后咽壁瓣(PPF)、咽缩肌成形术(SPP)、Furlow 腭裂修复术和颊黏膜肌瓣腭延长术(PL)。

结果测量

主要结局测量指标是术后语音改善情况,通过匹兹堡语音重量评分(PWSS)进行评估。

结果

97 例患者符合纳入标准。38 例曾行直线型初次腭裂修复术的患者接受了 Furlow 再修复;与 VPD 患者相比,这些患者明显更年轻(7.62 岁比 11.14 岁, < .001),PWSS 评估的 VPD 严重程度更高(OR 4.28, < .01,95%CI 1.46-12.56)。其中 21.1%的患者需要进一步的非修复性 VPD 手术。其余患者接受了非修复手术(26 例 PPF、22 例 SPP、11 例 PL);所有患者的 PWSS 总分和亚组 VPD 严重程度评分均有显著(配对 t 检验, < .001)降低,且手术类型间无改善差异。SPP 与所有原因的并发症(OR 2.79,95%CI 1.03-7.59, < .05)和低鼻音(OR 3.27,95%CI 1.112-9.630, < .05)均有统计学关联。

结论

Furlow 再修复可减少对额外 VPD 手术的需求。非修复性手术的语音效果相当,但 SPP 中并发症发生率增加。

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