Guangzhou Institute of Chemistry, Chinese Academy of Sciences, 510650 Guangzhou, P. R. China.
University of Chinese Academy of Sciences, 100000 Beijing, P. R. China.
Langmuir. 2023 Feb 21;39(7):2631-2640. doi: 10.1021/acs.langmuir.2c03071. Epub 2023 Feb 7.
One of the potential treatments for bacterial wound infections is photodynamic therapy. WO semiconductor materials can generate reactive oxygen species when exposed to light, which can inactivate bacteria. In this work, we improved their photocatalytic performance by doping WO with Cu. The wound dressing was prepared by loading Cu-WO into a highly biocompatible chitosan sponge. The composite sponge dressing showed significant inactivation of and , and in vitro toxicity assays on L929 cells demonstrated the biosafety of the dressing. Through in vivo wound healing trials, composite sponge dressings have been shown to accelerate wound healing, and this composite chitosan sponge can be possibly used for photodynamic therapy of bacterial wound infections.
一种治疗细菌性伤口感染的潜在方法是光动力疗法。WO 半导体材料在暴露于光时会产生活性氧物质，从而使细菌失活。在这项工作中，我们通过掺杂 Cu 来提高 WO 的光催化性能。将 Cu-WO 负载到高度生物相容的壳聚糖海绵中制备了伤口敷料。复合海绵敷料对 和 具有显著的灭活作用，对 L929 细胞的体外毒性试验表明敷料具有生物安全性。通过体内伤口愈合试验，复合海绵敷料已被证明能加速伤口愈合，这种复合壳聚糖海绵可用于光动力治疗细菌性伤口感染。
