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细胞外囊泡中的 microRNA-375 - 食管癌诊断的新型标志物。

MicroRNA-375 in extracellular vesicles - novel marker for esophageal cancer diagnosis.

机构信息

Department of Thoracic Surgery, The Naval Medical Center of PLA, Second Military Medical University, Shanghai, China.

Department of Cardiology, The Naval Medical Center of PLA, Second Military Medical University, Shanghai, China.

出版信息

Medicine (Baltimore). 2023 Feb 3;102(5):e32826. doi: 10.1097/MD.0000000000032826.

DOI:10.1097/MD.0000000000032826
PMID:36749234
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9901947/
Abstract

BACKGROUND

MicroRNAs have been confirmed to function as diagnostic biomarkers for esophageal cancer (EC). This study aimed to investigate the diagnostic potential of miR-375 in the plasma or extracellular vesicles (EVs) of esophageal cancers (ECs).

METHODS

miRNAs with diagnostic potential were identified through public database searches and validated through clinical sample testing. The diagnostic value of miR-375 in plasma and EVs was evaluated via receiver operating characteristic analysis and area under the curve. In addition, expression and survival analyses of the top ten target genes of miR-375 were conducted using the cancer genome atlas database.

RESULTS

MiR-375 was identified as a potential biomarker for ECs by searching the gene expression omnibus database. Results of clinical sample measurements showed that miR-375 in plasma or EVs was significantly different between ECs and controls ( P < .01), but did not differ by gender or age. receiver operating characteristic analysis demonstrated that miR-375 in EVs could function as a diagnostic marker for ECs, with a higher area under the curve (0.852) than that in plasma. The expression and survival analysis of the top ten target genes for miR-375 showed that only EIF4G3 was significantly associated with survival ( P < .05).

CONCLUSION

This research shows that miR-375, particularly in EVs, could serve as a biomarker for the diagnosis of ECs.

摘要

背景

MicroRNAs 已被证实可作为食管癌 (EC) 的诊断生物标志物。本研究旨在探讨 miR-375 在食管癌患者血浆或细胞外囊泡 (EVs) 中的诊断潜力。

方法

通过公共数据库搜索鉴定具有诊断潜力的 miRNAs，并通过临床样本测试进行验证。通过接受者操作特征分析和曲线下面积评估 miR-375 在血浆和 EVs 中的诊断价值。此外，使用癌症基因组图谱数据库对 miR-375 的前十个靶基因进行表达和生存分析。

结果

通过基因表达综合数据库搜索，鉴定出 miR-375 是 EC 的潜在生物标志物。临床样本测量结果表明，EC 患者血浆或 EVs 中的 miR-375 与对照组相比差异显著 (P<0.01)，但不受性别或年龄影响。接受者操作特征分析表明，EVs 中的 miR-375 可作为 EC 的诊断标志物，曲线下面积 (0.852) 高于血浆。miR-375 的前十个靶基因的表达和生存分析表明，只有 EIF4G3 与生存显著相关 (P<0.05)。

结论

本研究表明，miR-375，特别是在 EVs 中，可能作为 EC 诊断的生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ed/9901947/e49b2ad8aec1/medi-102-e32826-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ed/9901947/57fa9e57a5ba/medi-102-e32826-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ed/9901947/c4fdc3be2f22/medi-102-e32826-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ed/9901947/6e9e2f28843e/medi-102-e32826-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ed/9901947/6e0ccd25091b/medi-102-e32826-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ed/9901947/e68cc5f1cfb9/medi-102-e32826-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ed/9901947/e49b2ad8aec1/medi-102-e32826-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ed/9901947/57fa9e57a5ba/medi-102-e32826-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ed/9901947/c4fdc3be2f22/medi-102-e32826-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ed/9901947/6e9e2f28843e/medi-102-e32826-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ed/9901947/6e0ccd25091b/medi-102-e32826-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ed/9901947/e68cc5f1cfb9/medi-102-e32826-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b9ed/9901947/e49b2ad8aec1/medi-102-e32826-g006.jpg

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